Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Lery_10053-oxoacyl-ACP reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (251 aa)    
Predicted Functional Partners:
Lery_1668
Polyketide synthase module.
  
 0.960
Lery_1004
YcaC related amidohydrolase.
   
  0.913
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
   0.899
atoB
Acyl CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.
   
  0.771
fadA
3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.
   
  0.771
yfcY
beta-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.
   
  0.771
hisI
phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family.
       0.725
hisF
Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
       0.725
hisA
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
       0.725
hisH
Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
       0.725
Your Current Organism:
Legionella erythra
NCBI taxonomy Id: 448
Other names: ATCC 35303, CCUG 29667, CIP 103843, DSM 17644, JCM 7564, L. erythra, NCTC 11977, strain SE-32A-C8
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