STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
prpD2-methylcitrate dehydratase. (481 aa)    
Predicted Functional Partners:
prpB
2-methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
 
 
 0.996
prpC
2-methylcitrate synthase; Belongs to the citrate synthase family.
 
 0.996
gltA
Citrate synthase; Belongs to the citrate synthase family.
 
 
 0.927
acnA
Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
  
 
 0.764
fadB
3-hydroxyacyl CoA dehydrogenase oxidoreductase; Belongs to the enoyl-CoA hydratase/isomerase family.
  
 
  0.722
yfcX
Enoyl CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.
  
 
  0.722
icd
Isocitrate dehydrogenase.
  
 
 0.701
Lery_1099
Phosphate acetyl/butaryl transferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.
    
  0.694
acsA
acetyl-CoA synthetase.
  
 
 0.637
acsB
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
  
 
 0.637
Your Current Organism:
Legionella erythra
NCBI taxonomy Id: 448
Other names: ATCC 35303, CCUG 29667, CIP 103843, DSM 17644, JCM 7564, L. erythra, NCTC 11977, strain SE-32A-C8
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