| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Lery_1213 | Lery_2007 | Lery_1213 | Lery_2007 | Eukaryotic DNA topoisomerase I, catalytic core. | SNF2/RAD54 family transporter domain-containing protein. | 0.647 |
| Lery_1213 | Lery_2694 | Lery_1213 | Lery_2694 | Eukaryotic DNA topoisomerase I, catalytic core. | Peptide chain release factor. | 0.643 |
| Lery_1213 | dnaN | Lery_1213 | Lery_2814 | Eukaryotic DNA topoisomerase I, catalytic core. | DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] | 0.724 |
| Lery_1213 | gyrB | Lery_1213 | Lery_2816 | Eukaryotic DNA topoisomerase I, catalytic core. | DNA gyrase, subunit B (type II topoisomerase); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP [...] | 0.780 |
| Lery_1213 | parE | Lery_1213 | Lery_0121 | Eukaryotic DNA topoisomerase I, catalytic core. | DNA topoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. | 0.780 |
| Lery_1213 | prfB | Lery_1213 | Lery_0325 | Eukaryotic DNA topoisomerase I, catalytic core. | Peptide chain release factor 2; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. | 0.643 |
| Lery_1213 | recQ | Lery_1213 | Lery_2678 | Eukaryotic DNA topoisomerase I, catalytic core. | ATP-dependent DNA helicase RecQ. | 0.832 |
| Lery_1213 | rnhB | Lery_1213 | Lery_1169 | Eukaryotic DNA topoisomerase I, catalytic core. | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.834 |
| Lery_1213 | ykoU | Lery_1213 | Lery_0562 | Eukaryotic DNA topoisomerase I, catalytic core. | Putative ATP-dependent DNA ligase YkoU. | 0.859 |
| Lery_1213 | ykoV | Lery_1213 | Lery_0563 | Eukaryotic DNA topoisomerase I, catalytic core. | Putative DNA repair protein YkoV; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. | 0.748 |
| Lery_2007 | Lery_1213 | Lery_2007 | Lery_1213 | SNF2/RAD54 family transporter domain-containing protein. | Eukaryotic DNA topoisomerase I, catalytic core. | 0.647 |
| Lery_2007 | dnaN | Lery_2007 | Lery_2814 | SNF2/RAD54 family transporter domain-containing protein. | DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] | 0.911 |
| Lery_2007 | gyrB | Lery_2007 | Lery_2816 | SNF2/RAD54 family transporter domain-containing protein. | DNA gyrase, subunit B (type II topoisomerase); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP [...] | 0.659 |
| Lery_2007 | parE | Lery_2007 | Lery_0121 | SNF2/RAD54 family transporter domain-containing protein. | DNA topoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. | 0.659 |
| Lery_2007 | recQ | Lery_2007 | Lery_2678 | SNF2/RAD54 family transporter domain-containing protein. | ATP-dependent DNA helicase RecQ. | 0.842 |
| Lery_2007 | ykoU | Lery_2007 | Lery_0562 | SNF2/RAD54 family transporter domain-containing protein. | Putative ATP-dependent DNA ligase YkoU. | 0.474 |
| Lery_2694 | Lery_1213 | Lery_2694 | Lery_1213 | Peptide chain release factor. | Eukaryotic DNA topoisomerase I, catalytic core. | 0.643 |
| dnaN | Lery_1213 | Lery_2814 | Lery_1213 | DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] | Eukaryotic DNA topoisomerase I, catalytic core. | 0.724 |
| dnaN | Lery_2007 | Lery_2814 | Lery_2007 | DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] | SNF2/RAD54 family transporter domain-containing protein. | 0.911 |
| dnaN | gyrB | Lery_2814 | Lery_2816 | DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] | DNA gyrase, subunit B (type II topoisomerase); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP [...] | 0.851 |
