| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Lery_1213 | Lery_1900 | Lery_1213 | Lery_1900 | Eukaryotic DNA topoisomerase I, catalytic core. | ATP dependent DNA ligase. | 0.658 |
| Lery_1213 | Lery_2694 | Lery_1213 | Lery_2694 | Eukaryotic DNA topoisomerase I, catalytic core. | Peptide chain release factor. | 0.569 |
| Lery_1213 | gyrB | Lery_1213 | Lery_2816 | Eukaryotic DNA topoisomerase I, catalytic core. | DNA gyrase, subunit B (type II topoisomerase); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP [...] | 0.946 |
| Lery_1213 | parE | Lery_1213 | Lery_0121 | Eukaryotic DNA topoisomerase I, catalytic core. | DNA topoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. | 0.946 |
| Lery_1213 | polA | Lery_1213 | Lery_0793 | Eukaryotic DNA topoisomerase I, catalytic core. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.572 |
| Lery_1213 | prfB | Lery_1213 | Lery_0325 | Eukaryotic DNA topoisomerase I, catalytic core. | Peptide chain release factor 2; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. | 0.569 |
| Lery_1213 | recQ | Lery_1213 | Lery_2678 | Eukaryotic DNA topoisomerase I, catalytic core. | ATP-dependent DNA helicase RecQ. | 0.950 |
| Lery_1213 | rnhB | Lery_1213 | Lery_1169 | Eukaryotic DNA topoisomerase I, catalytic core. | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.879 |
| Lery_1213 | ykoU | Lery_1213 | Lery_0562 | Eukaryotic DNA topoisomerase I, catalytic core. | Putative ATP-dependent DNA ligase YkoU. | 0.829 |
| Lery_1213 | ykoV | Lery_1213 | Lery_0563 | Eukaryotic DNA topoisomerase I, catalytic core. | Putative DNA repair protein YkoV; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. | 0.747 |
| Lery_1900 | Lery_1213 | Lery_1900 | Lery_1213 | ATP dependent DNA ligase. | Eukaryotic DNA topoisomerase I, catalytic core. | 0.658 |
| Lery_1900 | polA | Lery_1900 | Lery_0793 | ATP dependent DNA ligase. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.980 |
| Lery_1900 | ykoU | Lery_1900 | Lery_0562 | ATP dependent DNA ligase. | Putative ATP-dependent DNA ligase YkoU. | 0.649 |
| Lery_1900 | ykoV | Lery_1900 | Lery_0563 | ATP dependent DNA ligase. | Putative DNA repair protein YkoV; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. | 0.573 |
| Lery_2694 | Lery_1213 | Lery_2694 | Lery_1213 | Peptide chain release factor. | Eukaryotic DNA topoisomerase I, catalytic core. | 0.569 |
| Lery_2694 | polA | Lery_2694 | Lery_0793 | Peptide chain release factor. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.439 |
| gyrB | Lery_1213 | Lery_2816 | Lery_1213 | DNA gyrase, subunit B (type II topoisomerase); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP [...] | Eukaryotic DNA topoisomerase I, catalytic core. | 0.946 |
| gyrB | polA | Lery_2816 | Lery_0793 | DNA gyrase, subunit B (type II topoisomerase); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP [...] | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.629 |
| gyrB | recQ | Lery_2816 | Lery_2678 | DNA gyrase, subunit B (type II topoisomerase); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP [...] | ATP-dependent DNA helicase RecQ. | 0.658 |
| parE | Lery_1213 | Lery_0121 | Lery_1213 | DNA topoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. | Eukaryotic DNA topoisomerase I, catalytic core. | 0.946 |