dlpA protein (Legionella erythra) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

dlpA

DlpA protein (isocitrate and isopropylmalate dehydrogenase family protein). (612 aa)

Predicted Functional Partners:

Lery_1579

0.989

icd

0.926

acnA

0.910

mvaB

0.906

Lery_1578

0.891

Lery_1576

0.884

prpC

0.853

gltA

0.847

korA

0.820

sucC

0.819

Your Current Organism:

Legionella erythra

NCBI taxonomy Id: 448
Other names: ATCC 35303, CCUG 29667, CIP 103843, DSM 17644, JCM 7564, L. erythra, NCTC 11977, strain SE-32A-C8

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Lery_1576	Lery_1578	Lery_1576	Lery_1578	Hypothetical protein.	Hypothetical protein.	0.866
Lery_1576	Lery_1579	Lery_1576	Lery_1579	Hypothetical protein.	4-hydroxy-2-oxovalerate aldolase.	0.792
Lery_1576	dlpA	Lery_1576	Lery_1577	Hypothetical protein.	DlpA protein (isocitrate and isopropylmalate dehydrogenase family protein).	0.884
Lery_1576	korA	Lery_1576	Lery_2260	Hypothetical protein.	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	0.470
Lery_1578	Lery_1576	Lery_1578	Lery_1576	Hypothetical protein.	Hypothetical protein.	0.866
Lery_1578	Lery_1579	Lery_1578	Lery_1579	Hypothetical protein.	4-hydroxy-2-oxovalerate aldolase.	0.840
Lery_1578	dlpA	Lery_1578	Lery_1577	Hypothetical protein.	DlpA protein (isocitrate and isopropylmalate dehydrogenase family protein).	0.891
Lery_1579	Lery_1576	Lery_1579	Lery_1576	4-hydroxy-2-oxovalerate aldolase.	Hypothetical protein.	0.792
Lery_1579	Lery_1578	Lery_1579	Lery_1578	4-hydroxy-2-oxovalerate aldolase.	Hypothetical protein.	0.840
Lery_1579	acnA	Lery_1579	Lery_1053	4-hydroxy-2-oxovalerate aldolase.	Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.	0.652
Lery_1579	dlpA	Lery_1579	Lery_1577	4-hydroxy-2-oxovalerate aldolase.	DlpA protein (isocitrate and isopropylmalate dehydrogenase family protein).	0.989
Lery_1579	korA	Lery_1579	Lery_2260	4-hydroxy-2-oxovalerate aldolase.	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	0.791
Lery_1579	mvaB	Lery_1579	Lery_0045	4-hydroxy-2-oxovalerate aldolase.	hydroxymethylglutaryl-CoA lyase.	0.505
Lery_1579	sucC	Lery_1579	Lery_2545	4-hydroxy-2-oxovalerate aldolase.	Succinyl CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.622
acnA	Lery_1579	Lery_1053	Lery_1579	Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.	4-hydroxy-2-oxovalerate aldolase.	0.652
acnA	dlpA	Lery_1053	Lery_1577	Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.	DlpA protein (isocitrate and isopropylmalate dehydrogenase family protein).	0.910
acnA	gltA	Lery_1053	Lery_1787	Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.	Citrate synthase; Belongs to the citrate synthase family.	0.991
acnA	icd	Lery_1053	Lery_2640	Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.	Isocitrate dehydrogenase.	0.988
acnA	korA	Lery_1053	Lery_2260	Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	0.606
acnA	mvaB	Lery_1053	Lery_0045	Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.	hydroxymethylglutaryl-CoA lyase.	0.652