STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fniIsopentenyl pyrophosphate isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (342 aa)    
Predicted Functional Partners:
mvaA_1
Hydroxymethylglutaryl CoA reductase; Belongs to the HMG-CoA reductase family.
   
 0.952
Lery_1730
Mevalonate diphosphate decarboxylase.
 
  
 0.921
Lery_1729
Mevalonate kinase.
 
  
 0.872
pksG
Polyketide biosynthesis 3-hydroxy-3-methylglutaryl-ACP synthase PksG.
 
 
 0.870
Lery_1742
Hypothetical protein.
    
 0.864
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
 
 0.856
Lery_2471
Mevalonate kinase.
 
  
 0.830
korA
2-oxoglutarate ferredoxin oxidoreductase subunit alpha.
    
 0.784
pykA
Pyruvate kinase II; Belongs to the pyruvate kinase family.
   
 0.758
mvaA_2
Hydroxymethylglutaryl CoA reductase; Belongs to the HMG-CoA reductase family.
   
 0.752
Your Current Organism:
Legionella erythra
NCBI taxonomy Id: 448
Other names: ATCC 35303, CCUG 29667, CIP 103843, DSM 17644, JCM 7564, L. erythra, NCTC 11977, strain SE-32A-C8
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