| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Lery_2781 | dcd | Lery_2781 | Lery_2713 | Nucleotide pyrophosphohydrolase. | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | 0.765 |
| Lery_2781 | dut | Lery_2781 | Lery_1569 | Nucleotide pyrophosphohydrolase. | Deoxyuridinetriphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.529 |
| Lery_2781 | ndk | Lery_2781 | Lery_1081 | Nucleotide pyrophosphohydrolase. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.694 |
| Lery_2781 | rir1 | Lery_2781 | Lery_2134 | Nucleotide pyrophosphohydrolase. | Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.652 |
| Lery_2781 | thyA | Lery_2781 | Lery_0788 | Nucleotide pyrophosphohydrolase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.820 |
| Lery_2781 | tmk | Lery_2781 | Lery_1194 | Nucleotide pyrophosphohydrolase. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.578 |
| coaD | dcd | Lery_2527 | Lery_2713 | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | 0.608 |
| coaD | dut | Lery_2527 | Lery_1569 | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | Deoxyuridinetriphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.451 |
| dcd | Lery_2781 | Lery_2713 | Lery_2781 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | Nucleotide pyrophosphohydrolase. | 0.765 |
| dcd | coaD | Lery_2713 | Lery_2527 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.608 |
| dcd | dnaA | Lery_2713 | Lery_2813 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | Chromosome replication initiator DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | 0.610 |
| dcd | dut | Lery_2713 | Lery_1569 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | Deoxyuridinetriphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.916 |
| dcd | ndk | Lery_2713 | Lery_1081 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.884 |
| dcd | rir1 | Lery_2713 | Lery_2134 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.861 |
| dcd | smpA | Lery_2713 | Lery_1418 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | tmRNA-binding small protein A. | 0.633 |
| dcd | thyA | Lery_2713 | Lery_0788 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.771 |
| dcd | tmk | Lery_2713 | Lery_1194 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.626 |
| dcd | yggV | Lery_2713 | Lery_1583 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.728 |
| dnaA | dcd | Lery_2813 | Lery_2713 | Chromosome replication initiator DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | 0.610 |
| dut | Lery_2781 | Lery_1569 | Lery_2781 | Deoxyuridinetriphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Nucleotide pyrophosphohydrolase. | 0.529 |
