Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
hemDUroporphyrinogen-III synthase; Family membership. (534 aa)    
Predicted Functional Partners:
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 0.999
sce0393
Putative siroheme synthase; Family membership.
 
 
 0.996
uroS
Porphobilinogen synthase; Belongs to the ALAD family.
 
 0.994
cobI
Precorrin-2-C20-methyltransferase; Family membership; Belongs to the precorrin methyltransferase family.
 
  
 0.971
cysI
Sulfite reductase (ferredoxin); High confidence in function and specificity; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
 
  
 0.961
hemE
Putative Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
  
 
 0.952
hemA
Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.951
sat1/cysC1
Sulfate adenylyltransferase; High confidence in function and specificity; In the N-terminal section; belongs to the APS kinase family.
  
  
 0.948
sat2/cysC2
Sulfate adenylyltransferase; High confidence in function and specificity; In the N-terminal section; belongs to the APS kinase family.
  
  
 0.948
sce6449
Putative transcriptional regulator.
 
 
 0.938
Your Current Organism:
Sorangium cellulosum So ce56
NCBI taxonomy Id: 448385
Other names: S. cellulosum So ce56, Sorangium cellulosum DSM 53796, Sorangium cellulosum str. So ce56, Sorangium cellulosum strain So ce56
Server load: medium (54%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.