Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
uroSPorphobilinogen synthase; Belongs to the ALAD family. (333 aa)    
Predicted Functional Partners:
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
 0.997
hemD
Uroporphyrinogen-III synthase; Family membership.
 
 0.994
hemL
Glutamate-1-semialdehyde 2,1-aminomutase; Family membership.
 
 
 0.991
mxcL
Glutamate-1-semialdehyde 2,1-aminomutase; High confidence in function and specificity; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
 
 
 0.953
hemA
Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.867
sce6449
Putative transcriptional regulator.
  
 
 0.832
hemE
Putative Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 
 0.822
sce0017
Hypothetical protein predicted by Glimmer/Critica.
       0.773
atpD
H(+)-transporting two-sector ATPase; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family.
 
 
  
 0.769
cobM
Precorrin-3B C(17)-methyltransferase.
 
   
 0.657
Your Current Organism:
Sorangium cellulosum So ce56
NCBI taxonomy Id: 448385
Other names: S. cellulosum So ce56, Sorangium cellulosum DSM 53796, Sorangium cellulosum str. So ce56, Sorangium cellulosum strain So ce56
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