STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
guaB1IMP dehydrogenase; Family membership. (514 aa)    
Predicted Functional Partners:
guaA1
GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.
 0.997
guaA2
Putative GMP synthase; Family membership.
 
 
 0.990
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
 
 
 0.990
purH
IMP cyclohydrolase; Family membership.
 
 
 0.989
guaB2
IMP dehydrogenase; Family membership.
 
 
0.951
surE1
Acid phosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.941
hpt
Hypoxanthine-phosphoribosyltransferase; Family membership; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
    
 0.941
yggV
Putative ribosomal protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
 
 0.936
sce8819
Hypothetical protein; 5-nucleotidase/23-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family.
   
 0.928
purL
Phosphoribosylformylglycinamidine synthase,probable; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
  
  
 0.922
Your Current Organism:
Sorangium cellulosum So ce56
NCBI taxonomy Id: 448385
Other names: S. cellulosum So ce56, Sorangium cellulosum DSM 53796, Sorangium cellulosum str. So ce56, Sorangium cellulosum strain So ce56
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