| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cbiA | cbiD | sce0213 | sce0239 | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Cobalamin biosynthesis protein CbiD, probable; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | 0.913 |
| cbiA | cbiP | sce0213 | sce0210 | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Adenosylcobyric acid synthase (glutamine-hydrolyzing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.997 |
| cbiA | cobD | sce0213 | sce0211 | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Adenosylcobinamide-phosphate synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.977 |
| cbiA | cobH | sce0213 | sce0238 | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | CobH protein; Family membership. | 0.997 |
| cbiA | cobM | sce0213 | sce0215 | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Precorrin-3B C(17)-methyltransferase. | 0.977 |
| cbiA | cobO | sce0213 | sce0214 | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. | 0.992 |
| cbiA | cobT1 | sce0213 | sce4943 | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.969 |
| cbiA | cobT2 | sce0213 | sce6908 | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.936 |
| cbiA | cobU | sce0213 | sce0212 | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Adenosylcobinamide-phosphate guanylyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | 0.988 |
| cbiA | sce3856 | sce0213 | sce3856 | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Hypothetical protein; Belongs to the Cob(I)alamin adenosyltransferase family. | 0.923 |
| cbiD | cbiA | sce0239 | sce0213 | Cobalamin biosynthesis protein CbiD, probable; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.913 |
| cbiD | cbiP | sce0239 | sce0210 | Cobalamin biosynthesis protein CbiD, probable; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Adenosylcobyric acid synthase (glutamine-hydrolyzing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.952 |
| cbiD | cobD | sce0239 | sce0211 | Cobalamin biosynthesis protein CbiD, probable; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Adenosylcobinamide-phosphate synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.890 |
| cbiD | cobH | sce0239 | sce0238 | Cobalamin biosynthesis protein CbiD, probable; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | CobH protein; Family membership. | 0.998 |
| cbiD | cobM | sce0239 | sce0215 | Cobalamin biosynthesis protein CbiD, probable; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Precorrin-3B C(17)-methyltransferase. | 0.969 |
| cbiD | cobO | sce0239 | sce0214 | Cobalamin biosynthesis protein CbiD, probable; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. | 0.444 |
| cbiD | cobT1 | sce0239 | sce4943 | Cobalamin biosynthesis protein CbiD, probable; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.649 |
| cbiD | cobT2 | sce0239 | sce6908 | Cobalamin biosynthesis protein CbiD, probable; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.528 |
| cbiD | cobU | sce0239 | sce0212 | Cobalamin biosynthesis protein CbiD, probable; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Adenosylcobinamide-phosphate guanylyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | 0.478 |
| cbiP | cbiA | sce0210 | sce0213 | Adenosylcobyric acid synthase (glutamine-hydrolyzing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.997 |