| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cbiA | cbiD | sce0213 | sce0239 | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Cobalamin biosynthesis protein CbiD, probable; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | 0.913 |
| cbiA | cbiG | sce0213 | sce0235 | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Uroporphyrin-III C-methyltransferase; Family membership. | 0.924 |
| cbiA | cbiH | sce0213 | sce0234 | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Precorrin-3B C(17)-methyltransferase; High confidence in function and specificity. | 0.886 |
| cbiA | cbiP | sce0213 | sce0210 | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Adenosylcobyric acid synthase (glutamine-hydrolyzing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.997 |
| cbiA | cobD | sce0213 | sce0211 | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Adenosylcobinamide-phosphate synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.977 |
| cbiA | cobH | sce0213 | sce0238 | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | CobH protein; Family membership. | 0.997 |
| cbiA | cobI | sce0213 | sce0236 | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Precorrin-2-C20-methyltransferase; Family membership; Belongs to the precorrin methyltransferase family. | 0.941 |
| cbiA | cobL | sce0213 | sce0237 | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Precorrin-6Y C(5,15)-methyltransferase (decarboxylating); High confidence in function and specificity. | 0.888 |
| cbiA | cobM | sce0213 | sce0215 | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Precorrin-3B C(17)-methyltransferase. | 0.977 |
| cbiA | cobU | sce0213 | sce0212 | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Adenosylcobinamide-phosphate guanylyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | 0.988 |
| cbiD | cbiA | sce0239 | sce0213 | Cobalamin biosynthesis protein CbiD, probable; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.913 |
| cbiD | cbiG | sce0239 | sce0235 | Cobalamin biosynthesis protein CbiD, probable; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Uroporphyrin-III C-methyltransferase; Family membership. | 0.999 |
| cbiD | cbiH | sce0239 | sce0234 | Cobalamin biosynthesis protein CbiD, probable; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Precorrin-3B C(17)-methyltransferase; High confidence in function and specificity. | 0.984 |
| cbiD | cbiP | sce0239 | sce0210 | Cobalamin biosynthesis protein CbiD, probable; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Adenosylcobyric acid synthase (glutamine-hydrolyzing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.952 |
| cbiD | cobD | sce0239 | sce0211 | Cobalamin biosynthesis protein CbiD, probable; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Adenosylcobinamide-phosphate synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.890 |
| cbiD | cobH | sce0239 | sce0238 | Cobalamin biosynthesis protein CbiD, probable; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | CobH protein; Family membership. | 0.998 |
| cbiD | cobI | sce0239 | sce0236 | Cobalamin biosynthesis protein CbiD, probable; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Precorrin-2-C20-methyltransferase; Family membership; Belongs to the precorrin methyltransferase family. | 0.993 |
| cbiD | cobL | sce0239 | sce0237 | Cobalamin biosynthesis protein CbiD, probable; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Precorrin-6Y C(5,15)-methyltransferase (decarboxylating); High confidence in function and specificity. | 0.994 |
| cbiD | cobM | sce0239 | sce0215 | Cobalamin biosynthesis protein CbiD, probable; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Precorrin-3B C(17)-methyltransferase. | 0.969 |
| cbiD | cobU | sce0239 | sce0212 | Cobalamin biosynthesis protein CbiD, probable; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Adenosylcobinamide-phosphate guanylyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | 0.478 |