node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aao | aceB | sce5330 | sce8725 | D-amino-acid oxidase; Family membership. | Malate synthase; High confidence in function and specificity; Belongs to the malate synthase family. | 0.824 |
aao | gcvT1 | sce5330 | sce2014 | D-amino-acid oxidase; Family membership. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.545 |
aao | glyA | sce5330 | sce6587 | D-amino-acid oxidase; Family membership. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.916 |
aao | ltaA | sce5330 | sce2044 | D-amino-acid oxidase; Family membership. | LtaA protein; Family membership. | 0.902 |
aao | sce0442 | sce5330 | sce0442 | D-amino-acid oxidase; Family membership. | Serine-pyruvate aminotransferase; Family membership. | 0.918 |
aao | sce8223 | sce5330 | sce8223 | D-amino-acid oxidase; Family membership. | Hypothetical protein. | 0.902 |
aao | soxB | sce5330 | sce0669 | D-amino-acid oxidase; Family membership. | Sarcosine oxidase, beta subunit; Family membership. | 0.900 |
aceB | aao | sce8725 | sce5330 | Malate synthase; High confidence in function and specificity; Belongs to the malate synthase family. | D-amino-acid oxidase; Family membership. | 0.824 |
aceB | sce0442 | sce8725 | sce0442 | Malate synthase; High confidence in function and specificity; Belongs to the malate synthase family. | Serine-pyruvate aminotransferase; Family membership. | 0.936 |
gcvH | gcvT1 | sce2013 | sce2014 | Glycine cleavage system protein H homologue; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |
gcvH | glyA | sce2013 | sce6587 | Glycine cleavage system protein H homologue; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.973 |
gcvH | sce0442 | sce2013 | sce0442 | Glycine cleavage system protein H homologue; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Serine-pyruvate aminotransferase; Family membership. | 0.918 |
gcvT1 | aao | sce2014 | sce5330 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | D-amino-acid oxidase; Family membership. | 0.545 |
gcvT1 | gcvH | sce2014 | sce2013 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | Glycine cleavage system protein H homologue; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
gcvT1 | glyA | sce2014 | sce6587 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.996 |
gcvT1 | sce0442 | sce2014 | sce0442 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | Serine-pyruvate aminotransferase; Family membership. | 0.930 |
gcvT1 | soxB | sce2014 | sce0669 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | Sarcosine oxidase, beta subunit; Family membership. | 0.953 |
glyA | aao | sce6587 | sce5330 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | D-amino-acid oxidase; Family membership. | 0.916 |
glyA | gcvH | sce6587 | sce2013 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Glycine cleavage system protein H homologue; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.973 |
glyA | gcvT1 | sce6587 | sce2014 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.996 |