node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
glyA | ilvA | sce6587 | sce3847 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative serine/threonine dehydratase; High confidence in function and specificity. | 0.927 |
glyA | pabB | sce6587 | sce5043 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Para-aminobenzoate synthase; High confidence in function and specificity. | 0.458 |
glyA | sce0442 | sce6587 | sce0442 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Serine-pyruvate aminotransferase; Family membership. | 0.926 |
glyA | serB | sce6587 | sce0663 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | SerB protein; High confidence in function and specificity. | 0.939 |
glyA | trpA | sce6587 | sce1103 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.932 |
glyA | trpB | sce6587 | sce1102 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.927 |
glyA | trpE | sce6587 | sce5044 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Anthranilate synthase; High confidence in function and specificity. | 0.458 |
ilvA | glyA | sce3847 | sce6587 | Putative serine/threonine dehydratase; High confidence in function and specificity. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.927 |
ilvA | sce0442 | sce3847 | sce0442 | Putative serine/threonine dehydratase; High confidence in function and specificity. | Serine-pyruvate aminotransferase; Family membership. | 0.929 |
ilvA | serB | sce3847 | sce0663 | Putative serine/threonine dehydratase; High confidence in function and specificity. | SerB protein; High confidence in function and specificity. | 0.924 |
ilvA | trpA | sce3847 | sce1103 | Putative serine/threonine dehydratase; High confidence in function and specificity. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.931 |
ilvA | trpB | sce3847 | sce1102 | Putative serine/threonine dehydratase; High confidence in function and specificity. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.944 |
ilvA | trpC | sce3847 | sce1101 | Putative serine/threonine dehydratase; High confidence in function and specificity. | Indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase; High confidence in function and specificity; Belongs to the TrpC family. | 0.512 |
pabB | glyA | sce5043 | sce6587 | Para-aminobenzoate synthase; High confidence in function and specificity. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.458 |
pabB | sce0620 | sce5043 | sce0620 | Para-aminobenzoate synthase; High confidence in function and specificity. | Probable anthranilate synthase component I; Family membership. | 0.995 |
pabB | trpA | sce5043 | sce1103 | Para-aminobenzoate synthase; High confidence in function and specificity. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.981 |
pabB | trpB | sce5043 | sce1102 | Para-aminobenzoate synthase; High confidence in function and specificity. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.977 |
pabB | trpC | sce5043 | sce1101 | Para-aminobenzoate synthase; High confidence in function and specificity. | Indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase; High confidence in function and specificity; Belongs to the TrpC family. | 0.999 |
pabB | trpD | sce5043 | sce1100 | Para-aminobenzoate synthase; High confidence in function and specificity. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.999 |
pabB | trpE | sce5043 | sce5044 | Para-aminobenzoate synthase; High confidence in function and specificity. | Anthranilate synthase; High confidence in function and specificity. | 0.999 |