| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cysB | glyA | sce8782 | sce6587 | Cystathionine beta-synthase; High confidence in function and specificity. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.943 |
| cysB | sce0438 | sce8782 | sce0438 | Cystathionine beta-synthase; High confidence in function and specificity. | Cystathionine beta-synthase; High confidence in function and specificity. | 0.915 |
| cysB | sdaA | sce8782 | sce1868 | Cystathionine beta-synthase; High confidence in function and specificity. | L-serine dehydratase; High confidence in function and specificity; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.919 |
| cysB | trpA | sce8782 | sce1103 | Cystathionine beta-synthase; High confidence in function and specificity. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.923 |
| cysB | trpB | sce8782 | sce1102 | Cystathionine beta-synthase; High confidence in function and specificity. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.911 |
| cysB | trpC | sce8782 | sce1101 | Cystathionine beta-synthase; High confidence in function and specificity. | Indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase; High confidence in function and specificity; Belongs to the TrpC family. | 0.455 |
| glyA | cysB | sce6587 | sce8782 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Cystathionine beta-synthase; High confidence in function and specificity. | 0.943 |
| glyA | pabB | sce6587 | sce5043 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Para-aminobenzoate synthase; High confidence in function and specificity. | 0.492 |
| glyA | sce0438 | sce6587 | sce0438 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Cystathionine beta-synthase; High confidence in function and specificity. | 0.943 |
| glyA | sdaA | sce6587 | sce1868 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | L-serine dehydratase; High confidence in function and specificity; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.969 |
| glyA | trpA | sce6587 | sce1103 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.930 |
| glyA | trpB | sce6587 | sce1102 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.925 |
| glyA | trpE | sce6587 | sce5044 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Anthranilate synthase; High confidence in function and specificity. | 0.492 |
| pabB | glyA | sce5043 | sce6587 | Para-aminobenzoate synthase; High confidence in function and specificity. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.492 |
| pabB | sce0620 | sce5043 | sce0620 | Para-aminobenzoate synthase; High confidence in function and specificity. | Probable anthranilate synthase component I; Family membership. | 0.994 |
| pabB | trpA | sce5043 | sce1103 | Para-aminobenzoate synthase; High confidence in function and specificity. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.986 |
| pabB | trpB | sce5043 | sce1102 | Para-aminobenzoate synthase; High confidence in function and specificity. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.983 |
| pabB | trpC | sce5043 | sce1101 | Para-aminobenzoate synthase; High confidence in function and specificity. | Indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase; High confidence in function and specificity; Belongs to the TrpC family. | 0.999 |
| pabB | trpD | sce5043 | sce1100 | Para-aminobenzoate synthase; High confidence in function and specificity. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.999 |
| pabB | trpE | sce5043 | sce5044 | Para-aminobenzoate synthase; High confidence in function and specificity. | Anthranilate synthase; High confidence in function and specificity. | 0.999 |
