Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ilvD1Dihydroxy-acid dehydratase; High confidence in function and specificity; Belongs to the IlvD/Edd family. (591 aa)    
Predicted Functional Partners:
faa
Fumarylacetoacetase family protein; Family membership.
 
  
 0.937
ilvC
Ketol-acid reductoisomerase (NADP(+)); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.932
ilvD3
Dihydroxy-acid dehydratase; Family membership; Belongs to the IlvD/Edd family.
  
  
 
0.920
leuC2
3-isopropylmalate dehydratase; Family membership.
 
  
 0.910
ilvN
Acetolactate synthase; Family membership.
 
 
 0.873
ilvB2
Acetolactate synthase; Family membership.
 
 0.823
ilvA
Putative serine/threonine dehydratase; High confidence in function and specificity.
 
 
 0.797
ilvE1
Branched-chain-amino-acid transaminase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 0.786
ilvE3
Branched-chain-amino-acid transaminase; High confidence in function and specificity.
  
 0.786
ilvE2
Branched-chain-amino-acid transaminase.
  
 0.777
Your Current Organism:
Sorangium cellulosum So ce56
NCBI taxonomy Id: 448385
Other names: S. cellulosum So ce56, Sorangium cellulosum DSM 53796, Sorangium cellulosum str. So ce56, Sorangium cellulosum strain So ce56
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