Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
pdhCDihydrolipoyllysine-residue acetyltransferase; High confidence in function and specificity. (478 aa)    
Predicted Functional Partners:
pdhB1
Pyruvate dehydrogenase (acetyl-transferring); High confidence in function and specificity.
 0.999
pdhB2
Pyruvate dehydrogenase (acetyl-transferring); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
 0.998
pdhA
Pyruvate dehydrogenase (acetyl-transferring); High confidence in function and specificity.
 
 0.997
pdhD
Pyruvate dehydrogenase E3 (dihydrolipoamide dehydrogenase); High confidence in function and specificity.
 0.996
sce8001
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring).
 
 0.995
aceE
Pyruvate dehydrogenase (acetyl-transferring); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 0.994
sucA
Oxoglutarate dehydrogenase (succinyl-transferring); High confidence in function and specificity.
 0.980
sce1736
Citrate synthase (EC 2.3.3.1).
  
 0.972
sucC
Succinate--CoA ligase (ADP-forming); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 0.971
cis1
Citrate synthase; Family membership; Belongs to the citrate synthase family.
  
 0.968
Your Current Organism:
Sorangium cellulosum So ce56
NCBI taxonomy Id: 448385
Other names: S. cellulosum So ce56, Sorangium cellulosum DSM 53796, Sorangium cellulosum str. So ce56, Sorangium cellulosum strain So ce56
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.