| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cysB | glyA | sce8782 | sce6587 | Cystathionine beta-synthase; High confidence in function and specificity. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.943 |
| cysB | sce0438 | sce8782 | sce0438 | Cystathionine beta-synthase; High confidence in function and specificity. | Cystathionine beta-synthase; High confidence in function and specificity. | 0.915 |
| cysB | sce5074 | sce8782 | sce5074 | Cystathionine beta-synthase; High confidence in function and specificity. | Putative serineacetyltransferase. | 0.922 |
| cysB | sce7326 | sce8782 | sce7326 | Cystathionine beta-synthase; High confidence in function and specificity. | O-acetyltransferase; Family membership. | 0.922 |
| cysB | sdaA | sce8782 | sce1868 | Cystathionine beta-synthase; High confidence in function and specificity. | L-serine dehydratase; High confidence in function and specificity; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.919 |
| cysB | serB | sce8782 | sce0663 | Cystathionine beta-synthase; High confidence in function and specificity. | SerB protein; High confidence in function and specificity. | 0.934 |
| cysB | srpH1 | sce8782 | sce3526 | Cystathionine beta-synthase; High confidence in function and specificity. | SrpH1 protein; Family membership. | 0.922 |
| cysB | srpH2 | sce8782 | sce4640 | Cystathionine beta-synthase; High confidence in function and specificity. | SrpH2 protein; Family membership. | 0.922 |
| cysB | trpA | sce8782 | sce1103 | Cystathionine beta-synthase; High confidence in function and specificity. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.923 |
| glyA | cysB | sce6587 | sce8782 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Cystathionine beta-synthase; High confidence in function and specificity. | 0.943 |
| glyA | sce0438 | sce6587 | sce0438 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Cystathionine beta-synthase; High confidence in function and specificity. | 0.943 |
| glyA | sce5074 | sce6587 | sce5074 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative serineacetyltransferase. | 0.830 |
| glyA | sce7326 | sce6587 | sce7326 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | O-acetyltransferase; Family membership. | 0.830 |
| glyA | sdaA | sce6587 | sce1868 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | L-serine dehydratase; High confidence in function and specificity; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.969 |
| glyA | serB | sce6587 | sce0663 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | SerB protein; High confidence in function and specificity. | 0.943 |
| glyA | srpH1 | sce6587 | sce3526 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | SrpH1 protein; Family membership. | 0.830 |
| glyA | srpH2 | sce6587 | sce4640 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | SrpH2 protein; Family membership. | 0.830 |
| glyA | trpA | sce6587 | sce1103 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.930 |
| ilvA | sdaA | sce3847 | sce1868 | Putative serine/threonine dehydratase; High confidence in function and specificity. | L-serine dehydratase; High confidence in function and specificity; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.936 |
| sce0438 | cysB | sce0438 | sce8782 | Cystathionine beta-synthase; High confidence in function and specificity. | Cystathionine beta-synthase; High confidence in function and specificity. | 0.915 |
