sce2016 protein (Sorangium cellulosum So ce56)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

sce2016

Putative pilin biogenesis protein; Family membership. (699 aa)

Predicted Functional Partners:

sce2019

0.955

sce2017

0.942

sce2020

0.941

pilA1

0.893

sce2021

0.863

pilO

0.798

sce2015

0.783

pilQ

0.765

sce0299

0.754

sce2018

0.737

Your Current Organism:

Sorangium cellulosum So ce56

NCBI taxonomy Id: 448385
Other names: S. cellulosum So ce56, Sorangium cellulosum DSM 53796, Sorangium cellulosum str. So ce56, Sorangium cellulosum strain So ce56

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
pilA1	pilO	sce4273	sce6186	Fimbrial protein pilA; Specificity unclear.	PilO protein; High confidence in function and specificity.	0.449
pilA1	pilQ	sce4273	sce6184	Fimbrial protein pilA; Specificity unclear.	Type 4 fimbrial biogenesis protein PilQ; Specificity unclear.	0.531
pilA1	sce0299	sce4273	sce0299	Fimbrial protein pilA; Specificity unclear.	LysM domain-containing protein; Unnamed protein product; Function unclear.	0.494
pilA1	sce2016	sce4273	sce2016	Fimbrial protein pilA; Specificity unclear.	Putative pilin biogenesis protein; Family membership.	0.893
pilA1	sce2017	sce4273	sce2017	Fimbrial protein pilA; Specificity unclear.	Hypothetical protein predicted by Glimmer/Critica.	0.815
pilA1	sce2019	sce4273	sce2019	Fimbrial protein pilA; Specificity unclear.	Hypothetical protein predicted by Glimmer/Critica.	0.866
pilA1	sce2020	sce4273	sce2020	Fimbrial protein pilA; Specificity unclear.	Hypothetical protein predicted by Glimmer/Critica.	0.871
pilA1	sce2021	sce4273	sce2021	Fimbrial protein pilA; Specificity unclear.	Hypothetical protein predicted by Glimmer/Critica.	0.507
pilO	pilA1	sce6186	sce4273	PilO protein; High confidence in function and specificity.	Fimbrial protein pilA; Specificity unclear.	0.449
pilO	pilQ	sce6186	sce6184	PilO protein; High confidence in function and specificity.	Type 4 fimbrial biogenesis protein PilQ; Specificity unclear.	0.992
pilO	sce0299	sce6186	sce0299	PilO protein; High confidence in function and specificity.	LysM domain-containing protein; Unnamed protein product; Function unclear.	0.965
pilO	sce2016	sce6186	sce2016	PilO protein; High confidence in function and specificity.	Putative pilin biogenesis protein; Family membership.	0.798
pilQ	pilA1	sce6184	sce4273	Type 4 fimbrial biogenesis protein PilQ; Specificity unclear.	Fimbrial protein pilA; Specificity unclear.	0.531
pilQ	pilO	sce6184	sce6186	Type 4 fimbrial biogenesis protein PilQ; Specificity unclear.	PilO protein; High confidence in function and specificity.	0.992
pilQ	sce0299	sce6184	sce0299	Type 4 fimbrial biogenesis protein PilQ; Specificity unclear.	LysM domain-containing protein; Unnamed protein product; Function unclear.	0.985
pilQ	sce2016	sce6184	sce2016	Type 4 fimbrial biogenesis protein PilQ; Specificity unclear.	Putative pilin biogenesis protein; Family membership.	0.765
sce0299	pilA1	sce0299	sce4273	LysM domain-containing protein; Unnamed protein product; Function unclear.	Fimbrial protein pilA; Specificity unclear.	0.494
sce0299	pilO	sce0299	sce6186	LysM domain-containing protein; Unnamed protein product; Function unclear.	PilO protein; High confidence in function and specificity.	0.965
sce0299	pilQ	sce0299	sce6184	LysM domain-containing protein; Unnamed protein product; Function unclear.	Type 4 fimbrial biogenesis protein PilQ; Specificity unclear.	0.985
sce0299	sce2016	sce0299	sce2016	LysM domain-containing protein; Unnamed protein product; Function unclear.	Putative pilin biogenesis protein; Family membership.	0.754

page 1 of 4

Network Stats

number of nodes:

3

number of edges:

2

average node degree:

1.33

avg. local clustering coefficient:

0.667

expected number of edges:

2

PPI enrichment p-value:

0.526

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:2000100

Regulation of establishment or maintenance of bipolar cell polarity regulating cell shape

7 of 11

2.32

5.13

1.84e-11

GO:0062200

RAM/MOR signaling pathway

6 of 6

2.52

5.08

9.76e-11

GO:0035556

Intracellular signal transduction

10 of 146

1.35

2.28

9.84e-11

GO:0072741

Protein localization to cell division site

3 of 4

2.39

2.13

9.71e-05

GO:0006468

Protein phosphorylation

7 of 85

1.43

2.03

3.37e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0106310

Protein serine kinase activity

7 of 66

1.54

2.26

3.04e-07

GO:0004674

Protein serine/threonine kinase activity

7 of 78

1.47

2.08

4.56e-07

GO:0005524

ATP binding

7 of 429

0.73

0.51

0.0091

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0071958

New mitotic spindle pole body

3 of 6

2.22

1.8

0.00036

GO:0051286

Cell tip

6 of 122

1.21

1.16

0.00028

GO:0032153

Cell division site

7 of 184

1.1

1.04

0.00023

GO:0005816

Spindle pole body

5 of 102

1.21

1.02

0.0013

GO:0044732

Mitotic spindle pole body

4 of 81

1.21

0.82

0.0084

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:532

Mixed, incl. RAM/MOR signaling pathway, and Septation initiation signaling

9 of 20

2.17

6.26

1.26e-15

CL:557

RAM/MOR signaling pathway

6 of 6

2.52

5.23

4.70e-11

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04113

Meiosis - yeast

4 of 80

1.22

0.8

0.0096

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-75153

Apoptotic execution phase

3 of 8

2.09

1.35

0.0026

MAP-109581

Apoptosis

3 of 15

1.82

1.11

0.0063

MAP-5357801

Programmed Cell Death

3 of 19

1.72

1.04

0.0079

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0032153

Cell division site

6 of 96

1.31

1.33

0.00014

GOCC:0005816

Spindle pole body

4 of 46

1.46

1.05

0.0041

GOCC:0071958

New mitotic spindle pole body

2 of 5

2.12

0.81

0.0317

GOCC:0044732

Mitotic spindle pole body

3 of 34

1.46

0.72

0.0317

GOCC:0030427

Site of polarized growth

3 of 48

1.31

0.61

0.0474

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0723

Serine/threonine-protein kinase

3 of 31

1.5

0.78

0.0228

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000719

Protein kinase domain

7 of 73

1.5

2.08

8.32e-07

IPR011009

Protein kinase-like domain superfamily

7 of 84

1.44

1.95

1.05e-06

IPR000961

AGC-kinase, C-terminal

3 of 6

2.22

1.73

0.00049

IPR017441

Protein kinase, ATP binding site

5 of 52

1.5

1.52

0.00016

IPR008271

Serine/threonine-protein kinase, active site

5 of 61

1.43

1.4

0.00026

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00133

Extension to Ser/Thr-type protein kinases

4 of 7

2.28

2.93

1.66e-06

SM00220

Serine/Threonine protein kinases, catalytic domain

6 of 50

1.6

2.24

9.83e-07

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