| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| aao | gcvP1 | sce5330 | sce2012 | D-amino-acid oxidase; Family membership. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.904 |
| aao | gcvP2 | sce5330 | sce9164 | D-amino-acid oxidase; Family membership. | Glycine dehydrogenase (decarboxylating); Family membership. | 0.904 |
| aao | glyA | sce5330 | sce6587 | D-amino-acid oxidase; Family membership. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.915 |
| aao | kbl | sce5330 | sce7278 | D-amino-acid oxidase; Family membership. | Glycine C-acetyltransferase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.906 |
| aao | ltaA | sce5330 | sce2044 | D-amino-acid oxidase; Family membership. | LtaA protein; Family membership. | 0.903 |
| aao | sce0442 | sce5330 | sce0442 | D-amino-acid oxidase; Family membership. | Serine-pyruvate aminotransferase; Family membership. | 0.923 |
| aao | sce8223 | sce5330 | sce8223 | D-amino-acid oxidase; Family membership. | Hypothetical protein. | 0.903 |
| gcvP1 | aao | sce2012 | sce5330 | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | D-amino-acid oxidase; Family membership. | 0.904 |
| gcvP1 | gcvP2 | sce2012 | sce9164 | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | Glycine dehydrogenase (decarboxylating); Family membership. | 0.999 |
| gcvP1 | glyA | sce2012 | sce6587 | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.974 |
| gcvP1 | kbl | sce2012 | sce7278 | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | Glycine C-acetyltransferase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.918 |
| gcvP1 | ltaA | sce2012 | sce2044 | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | LtaA protein; Family membership. | 0.923 |
| gcvP1 | sce0442 | sce2012 | sce0442 | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | Serine-pyruvate aminotransferase; Family membership. | 0.901 |
| gcvP1 | sce8093 | sce2012 | sce8093 | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | Putative oxidoreductase; Family membership; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.534 |
| gcvP1 | sce8223 | sce2012 | sce8223 | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | Hypothetical protein. | 0.923 |
| gcvP2 | aao | sce9164 | sce5330 | Glycine dehydrogenase (decarboxylating); Family membership. | D-amino-acid oxidase; Family membership. | 0.904 |
| gcvP2 | gcvP1 | sce9164 | sce2012 | Glycine dehydrogenase (decarboxylating); Family membership. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.999 |
| gcvP2 | glyA | sce9164 | sce6587 | Glycine dehydrogenase (decarboxylating); Family membership. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.987 |
| gcvP2 | kbl | sce9164 | sce7278 | Glycine dehydrogenase (decarboxylating); Family membership. | Glycine C-acetyltransferase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.916 |
| gcvP2 | ltaA | sce9164 | sce2044 | Glycine dehydrogenase (decarboxylating); Family membership. | LtaA protein; Family membership. | 0.923 |