| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cobB | cobB-2 | sce0596 | sce3874 | Transcriptional regulatory protein, Sir2 family; Belongs to the sirtuin family. Class III subfamily. | Hypothetical protein; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class II subfamily. | 0.920 |
| cobB | deoD | sce0596 | sce5862 | Transcriptional regulatory protein, Sir2 family; Belongs to the sirtuin family. Class III subfamily. | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.906 |
| cobB | nadE | sce0596 | sce3823 | Transcriptional regulatory protein, Sir2 family; Belongs to the sirtuin family. Class III subfamily. | NAD(+) synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. | 0.912 |
| cobB | nnrE | sce0596 | sce0321 | Transcriptional regulatory protein, Sir2 family; Belongs to the sirtuin family. Class III subfamily. | ADP-dependent (S)-NAD(P)H-hydrate dehydratase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to all [...] | 0.441 |
| cobB | sce3711 | sce0596 | sce3711 | Transcriptional regulatory protein, Sir2 family; Belongs to the sirtuin family. Class III subfamily. | Putative Isochorismatase hydrolase; Family membership. | 0.904 |
| cobB | sce7444 | sce0596 | sce7444 | Transcriptional regulatory protein, Sir2 family; Belongs to the sirtuin family. Class III subfamily. | Transcriptional regulatory protein, Sir2 family. | 0.924 |
| cobB-2 | cobB | sce3874 | sce0596 | Hypothetical protein; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class II subfamily. | Transcriptional regulatory protein, Sir2 family; Belongs to the sirtuin family. Class III subfamily. | 0.920 |
| cobB-2 | deoD | sce3874 | sce5862 | Hypothetical protein; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class II subfamily. | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.906 |
| cobB-2 | nadE | sce3874 | sce3823 | Hypothetical protein; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class II subfamily. | NAD(+) synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. | 0.912 |
| cobB-2 | sce3711 | sce3874 | sce3711 | Hypothetical protein; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class II subfamily. | Putative Isochorismatase hydrolase; Family membership. | 0.904 |
| cobB-2 | sce7444 | sce3874 | sce7444 | Hypothetical protein; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class II subfamily. | Transcriptional regulatory protein, Sir2 family. | 0.927 |
| deoD | cobB | sce5862 | sce0596 | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Transcriptional regulatory protein, Sir2 family; Belongs to the sirtuin family. Class III subfamily. | 0.906 |
| deoD | cobB-2 | sce5862 | sce3874 | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Hypothetical protein; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class II subfamily. | 0.906 |
| deoD | sce3711 | sce5862 | sce3711 | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Putative Isochorismatase hydrolase; Family membership. | 0.901 |
| deoD | sce3712 | sce5862 | sce3712 | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Putative Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | 0.907 |
| deoD | sce7444 | sce5862 | sce7444 | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Transcriptional regulatory protein, Sir2 family. | 0.906 |
| deoD | sce8297 | sce5862 | sce8297 | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Hypothetical protein. | 0.907 |
| nadE | cobB | sce3823 | sce0596 | NAD(+) synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. | Transcriptional regulatory protein, Sir2 family; Belongs to the sirtuin family. Class III subfamily. | 0.912 |
| nadE | cobB-2 | sce3823 | sce3874 | NAD(+) synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. | Hypothetical protein; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class II subfamily. | 0.912 |
| nadE | sce3711 | sce3823 | sce3711 | NAD(+) synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. | Putative Isochorismatase hydrolase; Family membership. | 0.655 |