Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ilvCKetol-acid reductoisomerase (NADP(+)); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (337 aa)    
Predicted Functional Partners:
ilvN
Acetolactate synthase; Family membership.
 
 
 0.999
ilvB2
Acetolactate synthase; Family membership.
 
 
 0.995
ilvD2
Dihydroxy-acid dehydratase; High confidence in function and specificity; Belongs to the IlvD/Edd family.
 
 
 0.993
ilvB1
Acetolactate synthase large subunit; Belongs to the TPP enzyme family.
 
 
 0.991
ilvG2
Acetolactate synthase; Family membership; Belongs to the TPP enzyme family.
 
 
 0.991
leuC2
3-isopropylmalate dehydratase; Family membership.
 
  
 0.973
leuC1
Isopropylmalate isomerase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
  
 0.970
ilvG1
Putative Acetolactate synthase; Family membership; Belongs to the TPP enzyme family.
 
 
 0.952
ilvD1
Dihydroxy-acid dehydratase; High confidence in function and specificity; Belongs to the IlvD/Edd family.
 
 
 0.932
leuD
Isopropylmalate isomerase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
  
 0.929
Your Current Organism:
Sorangium cellulosum So ce56
NCBI taxonomy Id: 448385
Other names: S. cellulosum So ce56, Sorangium cellulosum DSM 53796, Sorangium cellulosum str. So ce56, Sorangium cellulosum strain So ce56
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