Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
gmkPutative Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (212 aa)    
Predicted Functional Partners:
sce8819
Hypothetical protein; 5-nucleotidase/23-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family.
   
 0.979
guaA1
GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.
 
 
 0.964
hpt
Hypoxanthine-phosphoribosyltransferase; Family membership; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 
 0.951
yloC
Uncharacterized stress-induced protein.
  
    0.949
guaB2
IMP dehydrogenase; Family membership.
  
 
 0.939
purB
Adenylosuccinate lyase; Family membership; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
   
 0.930
rel
GTP diphosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
  
 
 0.929
ndk
Putative Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
   
 0.927
sce6063
Hypothetical protein predicted by Glimmer/Critica; Specificity unclear.
  
 
 0.926
guaA2
Putative GMP synthase; Family membership.
  
 
 0.922
Your Current Organism:
Sorangium cellulosum So ce56
NCBI taxonomy Id: 448385
Other names: S. cellulosum So ce56, Sorangium cellulosum DSM 53796, Sorangium cellulosum str. So ce56, Sorangium cellulosum strain So ce56
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.