Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
sce3856Hypothetical protein; Belongs to the Cob(I)alamin adenosyltransferase family. (237 aa)    
Predicted Functional Partners:
cobO
Cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids.
    
 0.933
cobU
Adenosylcobinamide-phosphate guanylyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.
    
 0.930
cobS
Probable cobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
    
 0.930
cbiP
Adenosylcobyric acid synthase (glutamine-hydrolyzing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
    
 0.926
cobD
Adenosylcobinamide-phosphate synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
    
 0.925
cbiA
Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.
    
 0.922
metH1
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
 
   
 0.579
metH2
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
 
   
 0.578
hemD
Uroporphyrinogen-III synthase; Family membership.
 
   
 0.563
sce3857
Hypothetical protein predicted by Glimmer/Critica.
       0.558
Your Current Organism:
Sorangium cellulosum So ce56
NCBI taxonomy Id: 448385
Other names: S. cellulosum So ce56, Sorangium cellulosum DSM 53796, Sorangium cellulosum str. So ce56, Sorangium cellulosum strain So ce56
Server load: low (16%) [HD]