STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sce4451DNA gyrase subunit A; High confidence in function and specificity. (800 aa)    
Predicted Functional Partners:
gyrB
DNA gyrase subunit B; High confidence in function and specificity.
 
 0.999
gyrB-2
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
 
 0.994
mukB
Cell division protein; Function unclear.
   
 
 0.844
yacG
Hypothetical protein; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
    
 
 0.780
sce8592
Putative membrane protein.
   
 
 0.766
metG2
Methionine--tRNA ligase 1; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
 
  
 0.762
metG1
Methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
  
  
 0.719
sce7337
Hypothetical protein.
  
   0.690
sce7338
Hypothetical protein; Family membership.
  
   0.690
pheT
phenylalanyl-tRNA synthetase, beta subunit; Family membership; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
  
  
 0.656
Your Current Organism:
Sorangium cellulosum So ce56
NCBI taxonomy Id: 448385
Other names: S. cellulosum So ce56, Sorangium cellulosum DSM 53796, Sorangium cellulosum str. So ce56, Sorangium cellulosum strain So ce56
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