| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| gyrB | metG1 | sce4452 | sce0127 | DNA gyrase subunit B; High confidence in function and specificity. | Methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.499 |
| gyrB | metG2 | sce4452 | sce7883 | DNA gyrase subunit B; High confidence in function and specificity. | Methionine--tRNA ligase 1; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.574 |
| gyrB | pheT | sce4452 | sce3390 | DNA gyrase subunit B; High confidence in function and specificity. | phenylalanyl-tRNA synthetase, beta subunit; Family membership; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.564 |
| gyrB | sce4451 | sce4452 | sce4451 | DNA gyrase subunit B; High confidence in function and specificity. | DNA gyrase subunit A; High confidence in function and specificity. | 0.999 |
| gyrB | yacG | sce4452 | sce1672 | DNA gyrase subunit B; High confidence in function and specificity. | Hypothetical protein; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase. | 0.779 |
| gyrB-2 | metG1 | sce8166 | sce0127 | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.499 |
| gyrB-2 | metG2 | sce8166 | sce7883 | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Methionine--tRNA ligase 1; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.594 |
| gyrB-2 | pheT | sce8166 | sce3390 | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | phenylalanyl-tRNA synthetase, beta subunit; Family membership; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.564 |
| gyrB-2 | sce4451 | sce8166 | sce4451 | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | DNA gyrase subunit A; High confidence in function and specificity. | 0.994 |
| gyrB-2 | yacG | sce8166 | sce1672 | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Hypothetical protein; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase. | 0.779 |
| metG1 | gyrB | sce0127 | sce4452 | Methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | DNA gyrase subunit B; High confidence in function and specificity. | 0.499 |
| metG1 | gyrB-2 | sce0127 | sce8166 | Methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.499 |
| metG1 | metG2 | sce0127 | sce7883 | Methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | Methionine--tRNA ligase 1; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.612 |
| metG1 | pheT | sce0127 | sce3390 | Methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | phenylalanyl-tRNA synthetase, beta subunit; Family membership; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.897 |
| metG1 | sce4451 | sce0127 | sce4451 | Methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | DNA gyrase subunit A; High confidence in function and specificity. | 0.719 |
| metG2 | gyrB | sce7883 | sce4452 | Methionine--tRNA ligase 1; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | DNA gyrase subunit B; High confidence in function and specificity. | 0.574 |
| metG2 | gyrB-2 | sce7883 | sce8166 | Methionine--tRNA ligase 1; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.594 |
| metG2 | metG1 | sce7883 | sce0127 | Methionine--tRNA ligase 1; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | Methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.612 |
| metG2 | pheT | sce7883 | sce3390 | Methionine--tRNA ligase 1; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | phenylalanyl-tRNA synthetase, beta subunit; Family membership; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.897 |
| metG2 | sce4451 | sce7883 | sce4451 | Methionine--tRNA ligase 1; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | DNA gyrase subunit A; High confidence in function and specificity. | 0.762 |