sce4451 protein (Sorangium cellulosum So ce56)

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[Homology]

Score

sce4451

DNA gyrase subunit A; High confidence in function and specificity. (800 aa)

Predicted Functional Partners:

gyrB

0.998

gyrB-2

0.991

mukB

0.791

sce8592

0.740

metG2

0.736

sce7337

0.730

sce7338

0.730

yacG

0.693

metG1

0.688

nusA

0.674

Your Current Organism:

Sorangium cellulosum So ce56

NCBI taxonomy Id: 448385
Other names: S. cellulosum So ce56, Sorangium cellulosum DSM 53796, Sorangium cellulosum str. So ce56, Sorangium cellulosum strain So ce56

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
gyrB	metG1	sce4452	sce0127	DNA gyrase subunit B; High confidence in function and specificity.	Methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.	0.415
gyrB	metG2	sce4452	sce7883	DNA gyrase subunit B; High confidence in function and specificity.	Methionine--tRNA ligase 1; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.	0.502
gyrB	sce4451	sce4452	sce4451	DNA gyrase subunit B; High confidence in function and specificity.	DNA gyrase subunit A; High confidence in function and specificity.	0.998
gyrB	yacG	sce4452	sce1672	DNA gyrase subunit B; High confidence in function and specificity.	Hypothetical protein; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.	0.689
gyrB-2	metG1	sce8166	sce0127	DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.	Methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.	0.415
gyrB-2	metG2	sce8166	sce7883	DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.	Methionine--tRNA ligase 1; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.	0.526
gyrB-2	sce4451	sce8166	sce4451	DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.	DNA gyrase subunit A; High confidence in function and specificity.	0.991
gyrB-2	yacG	sce8166	sce1672	DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.	Hypothetical protein; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.	0.689
metG1	gyrB	sce0127	sce4452	Methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.	DNA gyrase subunit B; High confidence in function and specificity.	0.415
metG1	gyrB-2	sce0127	sce8166	Methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.	DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.	0.415
metG1	metG2	sce0127	sce7883	Methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.	Methionine--tRNA ligase 1; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.	0.472
metG1	sce4451	sce0127	sce4451	Methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.	DNA gyrase subunit A; High confidence in function and specificity.	0.688
metG2	gyrB	sce7883	sce4452	Methionine--tRNA ligase 1; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.	DNA gyrase subunit B; High confidence in function and specificity.	0.502
metG2	gyrB-2	sce7883	sce8166	Methionine--tRNA ligase 1; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.	DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.	0.526
metG2	metG1	sce7883	sce0127	Methionine--tRNA ligase 1; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.	Methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.	0.472
metG2	sce4451	sce7883	sce4451	Methionine--tRNA ligase 1; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.	DNA gyrase subunit A; High confidence in function and specificity.	0.736
mukB	sce4451	sce5694	sce4451	Cell division protein; Function unclear.	DNA gyrase subunit A; High confidence in function and specificity.	0.791
nusA	sce4451	sce5800	sce4451	N utilization substance protein A; Participates in both transcription termination and antitermination.	DNA gyrase subunit A; High confidence in function and specificity.	0.674
sce4451	gyrB	sce4451	sce4452	DNA gyrase subunit A; High confidence in function and specificity.	DNA gyrase subunit B; High confidence in function and specificity.	0.998
sce4451	gyrB-2	sce4451	sce8166	DNA gyrase subunit A; High confidence in function and specificity.	DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.	0.991

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