node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aroC | aroE1 | sce4843 | sce1639 | 5-enolpyruvylshikimate-3-phosphate phospholyase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Shikimate dehydrogenase (NADP(+)); Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.882 |
aroC | dhbC | sce4843 | sce5042 | 5-enolpyruvylshikimate-3-phosphate phospholyase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | DhbC protein; High confidence in function and specificity. | 0.933 |
aroC | mxcD | sce4843 | sce3879 | 5-enolpyruvylshikimate-3-phosphate phospholyase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | MxcD protein; High confidence in function and specificity. | 0.904 |
aroC | trpE | sce4843 | sce5044 | 5-enolpyruvylshikimate-3-phosphate phospholyase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Anthranilate synthase; High confidence in function and specificity. | 0.968 |
aroE1 | aroC | sce1639 | sce4843 | Shikimate dehydrogenase (NADP(+)); Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 5-enolpyruvylshikimate-3-phosphate phospholyase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.882 |
aroE1 | dhbC | sce1639 | sce5042 | Shikimate dehydrogenase (NADP(+)); Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | DhbC protein; High confidence in function and specificity. | 0.907 |
aroE1 | mxcD | sce1639 | sce3879 | Shikimate dehydrogenase (NADP(+)); Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | MxcD protein; High confidence in function and specificity. | 0.868 |
aroE1 | trpE | sce1639 | sce5044 | Shikimate dehydrogenase (NADP(+)); Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | Anthranilate synthase; High confidence in function and specificity. | 0.594 |
dhbC | aroC | sce5042 | sce4843 | DhbC protein; High confidence in function and specificity. | 5-enolpyruvylshikimate-3-phosphate phospholyase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.933 |
dhbC | aroE1 | sce5042 | sce1639 | DhbC protein; High confidence in function and specificity. | Shikimate dehydrogenase (NADP(+)); Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.907 |
dhbC | menD | sce5042 | sce3012 | DhbC protein; High confidence in function and specificity. | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). | 0.990 |
dhbC | mxcD | sce5042 | sce3879 | DhbC protein; High confidence in function and specificity. | MxcD protein; High confidence in function and specificity. | 0.919 |
dhbC | mxcE | sce5042 | sce3880 | DhbC protein; High confidence in function and specificity. | (2,3-dihydroxybenzoyl)adenylate synthase; High confidence in function and specificity. | 0.941 |
dhbC | mxcF | sce5042 | sce3881 | DhbC protein; High confidence in function and specificity. | Isochorismatase; High confidence in function and specificity. | 0.996 |
dhbC | sce0345 | sce5042 | sce0345 | DhbC protein; High confidence in function and specificity. | NRPS/PKS hybrid; Family membership. | 0.912 |
dhbC | sce2387 | sce5042 | sce2387 | DhbC protein; High confidence in function and specificity. | Non-ribosomal peptide synthetase; Family membership. | 0.918 |
dhbC | sce6823 | sce5042 | sce6823 | DhbC protein; High confidence in function and specificity. | NRPS/PKS hybrid. | 0.955 |
dhbC | trpE | sce5042 | sce5044 | DhbC protein; High confidence in function and specificity. | Anthranilate synthase; High confidence in function and specificity. | 0.904 |
menD | dhbC | sce3012 | sce5042 | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). | DhbC protein; High confidence in function and specificity. | 0.990 |
menD | mxcD | sce3012 | sce3879 | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). | MxcD protein; High confidence in function and specificity. | 0.979 |