Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
LHA_0114Homologs of previously reported genes of unknown function. (117 aa)    
Predicted Functional Partners:
cycA
Function of strongly homologous gene; enzyme.
       0.718
ctaD
Putative cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
     
 0.496
coxB
Cytochrome c oxidase subunit 2; Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).
     
 0.485
trpE(G
Anthranilate synthase [Includes: Glutamine amidotransferase].
 
   
 0.445
LHA_2845
Homologs of previously reported genes of unknown function.
  
  
 0.440
LHA_1269
Putative Cellulase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the glycosyl hydrolase 5 (cellulase A) family.
  
     0.423
mt:CoIII
Cytochrome c oxidase subunit 3.
     
 0.411
LHA_2268
Putative Mitogen-activated protein kinase kinase kinase [STPK domain]; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
    0.404
LHA_1749
Membrane-fusion protein [coiled-coil domain]; Gene remnant;/product='fragment of protein of unknown function'.
  
     0.402
LHA_0118
Cytochrome c oxidase assembly protein; Function of strongly homologous gene; enzyme.
       0.401
Your Current Organism:
Legionella hackeliae
NCBI taxonomy Id: 449
Other names: ATCC 35250, CCUG 31232, CCUG 31232 A, CIP 103844, DSM 19214, JCM 7563, L. hackeliae, NCTC 11979, strain Lansing 2
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