STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
iolAMethylmalonate semialdehyde dehydrogenase [acylating]. (499 aa)    
Predicted Functional Partners:
mmsB
Putative 3-hydroxyisobutyrate dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the HIBADH-related family.
 
 
 0.977
acsA
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
  
 0.977
LHA_2550
Bifunctional enoyl-CoA hydratase/phosphate acetyltransferase.
  
 0.949
gabT
4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
 0.941
prpC
2-methylcitrate synthase; Belongs to the citrate synthase family.
  
 0.930
yfcX
YfcX enoyl CoA hydratase; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
  
 0.927
pta
Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.
  
 
 0.925
alh
Putative aldehyde dehydrogenase family 7 member A1 homolog; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the aldehyde dehydrogenase family.
  
  
 
0.911
accC
Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
    
 0.908
phbA
Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.
   
 0.908
Your Current Organism:
Legionella hackeliae
NCBI taxonomy Id: 449
Other names: ATCC 35250, CCUG 31232, CCUG 31232 A, CIP 103844, DSM 19214, JCM 7563, L. hackeliae, NCTC 11979, strain Lansing 2
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