Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mmsBPutative 3-hydroxyisobutyrate dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the HIBADH-related family. (300 aa)    
Predicted Functional Partners:
LHA_1307
3-hydroxyisobutyryl-CoA hydrolase; Function of strongly homologous gene; enzyme.
  
 0.985
iolA
Methylmalonate semialdehyde dehydrogenase [acylating].
 
 
 0.984
acsA
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
  
 
 0.974
gabT
4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
     
  0.900
LHA_2550
Bifunctional enoyl-CoA hydratase/phosphate acetyltransferase.
    
 0.829
prpC
2-methylcitrate synthase; Belongs to the citrate synthase family.
  
 
 0.824
LHA_1574
Branched-chain alpha-keto acid dehydrogenase subunit E2.
   
 
 0.812
pta
Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.
     
  0.800
LHA_0280
Homologs of previously reported genes of unknown function.
  
    0.762
LHA_0279
Protein of unknown function; No homology to any previously reported sequences.
       0.667
Your Current Organism:
Legionella hackeliae
NCBI taxonomy Id: 449
Other names: ATCC 35250, CCUG 31232, CCUG 31232 A, CIP 103844, DSM 19214, JCM 7563, L. hackeliae, NCTC 11979, strain Lansing 2
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