Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LHA_0495Methyltransferase [TPR domain][Sel1-like domain]; Function of strongly homologous gene; enzyme. (568 aa)    
Predicted Functional Partners:
LHA_2597
Protein of unknown function [coiled-coil domain]; No homology to any previously reported sequences.
   
 0.911
LHA_0497
Nucleoside-triphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
   
   0.820
elaA
Protein elaA.
       0.812
LHA_2609
Putative Aspartate racemase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
 
 0.697
dnaK
Chaperone protein dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
 
 0.662
LHA_3255
Hyaluronan synthase; Function of strongly homologous gene; enzyme.
  
 
 0.630
LHA_1667
Homologs of previously reported genes of unknown function.
   
 
 0.627
LHA_1827
Histone deacetylase superfamily.
  
 
  0.617
htpG
Chaperone protein htpG; Molecular chaperone. Has ATPase activity.
   
 0.594
LHA_2521
Conserved protein of unknown function [TPR Domain]; Homologs of previously reported genes of unknown function.
 
   
 0.579
Your Current Organism:
Legionella hackeliae
NCBI taxonomy Id: 449
Other names: ATCC 35250, CCUG 31232, CCUG 31232 A, CIP 103844, DSM 19214, JCM 7563, L. hackeliae, NCTC 11979, strain Lansing 2
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