gmk protein (Legionella hackeliae) - STRING interaction network

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gmk

Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (209 aa)

Predicted Functional Partners:

guaA

0.977

spoT

0.965

yicC

0.959

rpoZ

0.939

LHA_1343

0.932

hpt

0.931

ndk

0.925

purB

0.924

nrdA

0.914

surE

0.912

Your Current Organism:

Legionella hackeliae

NCBI taxonomy Id: 449
Other names: ATCC 35250, CCUG 31232, CCUG 31232 A, CIP 103844, DSM 19214, JCM 7563, L. hackeliae, NCTC 11979, strain Lansing 2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LHA_1343	gmk	LHA_1343	LHA_0697	Putative Hypoxanthine phosphoribosyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.932
LHA_1343	guaA	LHA_1343	LHA_1436	Putative Hypoxanthine phosphoribosyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	0.943
LHA_1343	hpt	LHA_1343	LHA_1633	Putative Hypoxanthine phosphoribosyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	Hypoxanthine phosphoribosyltransferase.	0.925
LHA_1343	surE	LHA_1343	LHA_1938	Putative Hypoxanthine phosphoribosyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	5'-nucleotidase surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.	0.914
gmk	LHA_1343	LHA_0697	LHA_1343	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Putative Hypoxanthine phosphoribosyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	0.932
gmk	guaA	LHA_0697	LHA_1436	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	0.977
gmk	hpt	LHA_0697	LHA_1633	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Hypoxanthine phosphoribosyltransferase.	0.931
gmk	ndk	LHA_0697	LHA_1586	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	0.925
gmk	nrdA	LHA_0697	LHA_2237	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Ribonucleoside-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.914
gmk	purB	LHA_0697	LHA_1225	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.924
gmk	rpoZ	LHA_0697	LHA_0698	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.	0.939
gmk	spoT	LHA_0697	LHA_0699	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Bifunctional (p)ppGpp synthase/hydrolase SpoT [Includes: GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.	0.965
gmk	surE	LHA_0697	LHA_1938	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	5'-nucleotidase surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.	0.912
gmk	yicC	LHA_0697	LHA_0696	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Homologs of previously reported genes of unknown function.	0.959
guaA	LHA_1343	LHA_1436	LHA_1343	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	Putative Hypoxanthine phosphoribosyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	0.943
guaA	gmk	LHA_1436	LHA_0697	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.977
guaA	hpt	LHA_1436	LHA_1633	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	Hypoxanthine phosphoribosyltransferase.	0.943
guaA	ndk	LHA_1436	LHA_1586	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	0.698
guaA	nrdA	LHA_1436	LHA_2237	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	Ribonucleoside-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.744
guaA	purB	LHA_1436	LHA_1225	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.944