STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LHA_0707Site specific recombinase, phage integrase. (406 aa)    
Predicted Functional Partners:
LHA_0943
Protein of unknown function; No homology to any previously reported sequences.
  
   
 0.516
topA
DNA topoisomerase; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA superc [...]
  
  
 0.511
LHA_1899
Sodium/hydrogen antiporter.
  
     0.500
LHA_0827
Homologs of previously reported genes of unknown function.
   
    0.495
sdhD
Succinate dehydrogenase hydrophobic membrane anchor subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH).
  
     0.475
dotA
Component of the Dot/Icm secretion system; Function of strongly homologous gene; membrane component.
  
     0.458
icmJ
IcmJ protein.
  
   
 0.423
LHA_1417
Putative Enhanced entry protein EnhA; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; cell process.
  
     0.418
LHA_0148
Peptidase S24-like domain protein; Function of strongly homologous gene; enzyme.
 
  
 0.413
LHA_0571
Homologs of previously reported genes of unknown function.
  
     0.401
Your Current Organism:
Legionella hackeliae
NCBI taxonomy Id: 449
Other names: ATCC 35250, CCUG 31232, CCUG 31232 A, CIP 103844, DSM 19214, JCM 7563, L. hackeliae, NCTC 11979, strain Lansing 2
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.