LHA_0721 protein (Legionella hackeliae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

LHA_0721

Smr domain protein, DNA mismatch repair protein-like protein. (183 aa)

Predicted Functional Partners:

LHA_0725

0.612

rpmF

0.580

udk

0.578

prmB

0.578

aroC

0.578

rpsN

0.561

rpmB

0.561

rplY

0.542

rpoZ

0.542

rplW

0.530

Your Current Organism:

Legionella hackeliae

NCBI taxonomy Id: 449
Other names: ATCC 35250, CCUG 31232, CCUG 31232 A, CIP 103844, DSM 19214, JCM 7563, L. hackeliae, NCTC 11979, strain Lansing 2

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LHA_0721	LHA_0725	LHA_0721	LHA_0725	Smr domain protein, DNA mismatch repair protein-like protein.	Homologs of previously reported genes of unknown function.	0.612
LHA_0721	aroC	LHA_0721	LHA_0723	Smr domain protein, DNA mismatch repair protein-like protein.	Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.	0.578
LHA_0721	prmB	LHA_0721	LHA_0722	Smr domain protein, DNA mismatch repair protein-like protein.	Uncharacterized adenine-specific methylase VC_2118; Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue; Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily.	0.578
LHA_0721	rplW	LHA_0721	LHA_0341	Smr domain protein, DNA mismatch repair protein-like protein.	50S ribosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family.	0.530
LHA_0721	rplY	LHA_0721	LHA_0622	Smr domain protein, DNA mismatch repair protein-like protein.	50S ribosomal protein L25; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.	0.542
LHA_0721	rpmB	LHA_0721	LHA_0591	Smr domain protein, DNA mismatch repair protein-like protein.	50S ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family.	0.561
LHA_0721	rpmF	LHA_0721	LHA_1784	Smr domain protein, DNA mismatch repair protein-like protein.	50S ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family.	0.580
LHA_0721	rpoZ	LHA_0721	LHA_0698	Smr domain protein, DNA mismatch repair protein-like protein.	DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.	0.542
LHA_0721	rpsN	LHA_0721	LHA_0352	Smr domain protein, DNA mismatch repair protein-like protein.	30S ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family.	0.561
LHA_0721	udk	LHA_0721	LHA_0720	Smr domain protein, DNA mismatch repair protein-like protein.	Uridine kinase.	0.578
LHA_0725	LHA_0721	LHA_0725	LHA_0721	Homologs of previously reported genes of unknown function.	Smr domain protein, DNA mismatch repair protein-like protein.	0.612
LHA_0725	aroC	LHA_0725	LHA_0723	Homologs of previously reported genes of unknown function.	Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.	0.548
LHA_0725	prmB	LHA_0725	LHA_0722	Homologs of previously reported genes of unknown function.	Uncharacterized adenine-specific methylase VC_2118; Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue; Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily.	0.548
aroC	LHA_0721	LHA_0723	LHA_0721	Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.	Smr domain protein, DNA mismatch repair protein-like protein.	0.578
aroC	LHA_0725	LHA_0723	LHA_0725	Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.	Homologs of previously reported genes of unknown function.	0.548
aroC	prmB	LHA_0723	LHA_0722	Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.	Uncharacterized adenine-specific methylase VC_2118; Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue; Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily.	0.847
aroC	udk	LHA_0723	LHA_0720	Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.	Uridine kinase.	0.438
prmB	LHA_0721	LHA_0722	LHA_0721	Uncharacterized adenine-specific methylase VC_2118; Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue; Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily.	Smr domain protein, DNA mismatch repair protein-like protein.	0.578
prmB	LHA_0725	LHA_0722	LHA_0725	Uncharacterized adenine-specific methylase VC_2118; Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue; Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily.	Homologs of previously reported genes of unknown function.	0.548
prmB	aroC	LHA_0722	LHA_0723	Uncharacterized adenine-specific methylase VC_2118; Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue; Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily.	Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.	0.847