STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
pilETfp pilus assembly protein, major type IV pilin class A; Function of strongly homologous gene; structure; Belongs to the N-Me-Phe pilin family. (135 aa)    
Predicted Functional Partners:
LHA_2167
Fimbrial assembly protein pilQ (fragment).
 
   
 0.728
bolA
Protein BolA; Belongs to the BolA/IbaG family.
       0.719
asd
Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family.
      
 0.665
LHA_0939
Homologs of previously reported genes of unknown function.
       0.612
LHA_2150
Putative Type 4 fimbrial biogenesis protein PilE; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.
 
   
 0.599
pilD
Type 4 prepilin-like proteins leader peptide-processing enzyme [Includes: Leader peptidase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.
 
   
 0.560
dnaA
Chromosomal replication initiator protein dnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family.
      
 0.475
pilB
Type 4 fimbrial assembly protein pilB.
 
  
 0.471
pilC
Type 4 fimbrial assembly protein pilC.
 
   
 0.466
LHA_2171
Protein of unknown function; No homology to any previously reported sequences.
 
   
 0.460
Your Current Organism:
Legionella hackeliae
NCBI taxonomy Id: 449
Other names: ATCC 35250, CCUG 31232, CCUG 31232 A, CIP 103844, DSM 19214, JCM 7563, L. hackeliae, NCTC 11979, strain Lansing 2
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