Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
LHA_0970Homologs of previously reported genes of unknown function. (482 aa)    
Predicted Functional Partners:
coxB
Cytochrome c oxidase subunit 2; Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).
   
 
 0.901
LHA_0969
Sensory box histidine kinase/response regulator.
 
     0.780
icmT
Component of the Dot/Icm secretion system; Function of strongly homologous gene; factor.
  
     0.633
icmJ
IcmJ protein.
  
     0.616
fumB
Fumarate hydratase, class I, anaerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
   
  
 0.612
icmK/dotH
Component of the Dot/Icm secretion system; Function of strongly homologous gene; structure.
  
     0.599
LHA_3180
Homologs of previously reported genes of unknown function.
  
     0.595
dotA
Component of the Dot/Icm secretion system; Function of strongly homologous gene; membrane component.
  
     0.588
LHA_1084
Homologs of previously reported genes of unknown function.
  
     0.587
LHA_0971
Deoxyguanosinetriphosphate triphosphohydrolase-like protein; Belongs to the dGTPase family. Type 2 subfamily.
 
     0.581
Your Current Organism:
Legionella hackeliae
NCBI taxonomy Id: 449
Other names: ATCC 35250, CCUG 31232, CCUG 31232 A, CIP 103844, DSM 19214, JCM 7563, L. hackeliae, NCTC 11979, strain Lansing 2
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