Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ldhLeucine dehydrogenase; Function of strongly homologous gene; enzyme; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (358 aa)    
Predicted Functional Partners:
LHA_2872
2-oxoisovalerate dehydrogenase, E1 component, alpha and beta fusion.
 
 
 0.992
pdhA
Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
  
 
 0.961
pdhB
Pyruvate dehydrogenase E1 component subunit beta.
  
 
 0.953
ilvE
Branched-chain-amino-acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 
 0.932
LHA_2550
Bifunctional enoyl-CoA hydratase/phosphate acetyltransferase.
  
  
 0.868
korA
2-oxoglutarate synthase subunit korA; Function of strongly homologous gene; enzyme.
  
  
 0.791
mdmC
O-methyltransferase mdmC.
       0.773
LHA_2415
Putative glutamate synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the glutamate synthase family.
  
 
 0.743
lly
4-hydroxyphenylpyruvate dioxygenase.
 
   
 0.729
putA
Bifunctional protein putA [Includes: Proline dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.
  
  
 0.720
Your Current Organism:
Legionella hackeliae
NCBI taxonomy Id: 449
Other names: ATCC 35250, CCUG 31232, CCUG 31232 A, CIP 103844, DSM 19214, JCM 7563, L. hackeliae, NCTC 11979, strain Lansing 2
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.