sdaA protein (Legionella hackeliae) - STRING interaction network

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Score

sdaA

L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (458 aa)

Predicted Functional Partners:

glyA

0.963

trpA

0.914

LHA_2612

0.914

pssA

0.900

trpB

0.900

metC

0.838

mip

0.712

fumB

0.648

ampG

0.612

gcvT

0.543

Your Current Organism:

Legionella hackeliae

NCBI taxonomy Id: 449
Other names: ATCC 35250, CCUG 31232, CCUG 31232 A, CIP 103844, DSM 19214, JCM 7563, L. hackeliae, NCTC 11979, strain Lansing 2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LHA_2612	glyA	LHA_2612	LHA_2325	Putative phosphoserine phosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.937
LHA_2612	pssA	LHA_2612	LHA_0582	Putative phosphoserine phosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.	CDP-diacylglycerol-serine-O- phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	0.901
LHA_2612	sdaA	LHA_2612	LHA_1216	Putative phosphoserine phosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.	L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	0.914
LHA_2612	trpA	LHA_2612	LHA_1916	Putative phosphoserine phosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.	Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	0.900
LHA_2612	trpB	LHA_2612	LHA_1917	Putative phosphoserine phosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.	Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	0.915
ampG	mip	LHA_1218	LHA_1217	Protein AmpG.	Outer membrane protein MIP.	0.690
ampG	sdaA	LHA_1218	LHA_1216	Protein AmpG.	L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	0.612
fumB	glyA	LHA_2524	LHA_2325	Fumarate hydratase, class I, anaerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.410
fumB	sdaA	LHA_2524	LHA_1216	Fumarate hydratase, class I, anaerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.	L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	0.648
gcvT	glyA	LHA_0233	LHA_2325	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.998
gcvT	sdaA	LHA_0233	LHA_1216	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.	L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	0.543
glyA	LHA_2612	LHA_2325	LHA_2612	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Putative phosphoserine phosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.	0.937
glyA	fumB	LHA_2325	LHA_2524	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Fumarate hydratase, class I, anaerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.	0.410
glyA	gcvT	LHA_2325	LHA_0233	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.	0.998
glyA	pssA	LHA_2325	LHA_0582	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	CDP-diacylglycerol-serine-O- phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	0.900
glyA	sdaA	LHA_2325	LHA_1216	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	0.963
glyA	trpA	LHA_2325	LHA_1916	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	0.931
glyA	trpB	LHA_2325	LHA_1917	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	0.925
metC	sdaA	LHA_2062	LHA_1216	Cystathionine beta-lyase.	L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	0.838
mip	ampG	LHA_1217	LHA_1218	Outer membrane protein MIP.	Protein AmpG.	0.690