STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aprDAlkaline protease secretion ATP-binding protein AprD. (573 aa)    
Predicted Functional Partners:
LHA_1274
Type I secretion membrane fusion protein, HlyD; Function of strongly homologous gene; transporter.
 
  
 0.962
metN
Methionine import ATP-binding protein MetN; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.
 
     
0.763
LHA_1273
Protein of unknown function; No homology to any previously reported sequences.
 
 
 0.762
lssD
Legionella secretion system protein D.
 
  
 0.729
LHA_1276
Conserved protein of unknown function [Hemolysin-type calcium-binding region]; Homologs of previously reported genes of unknown function.
 
 
 0.721
tolC
Outer membrane protein TolC.
  
  
 0.631
LHA_2118
Type I secretion outer membrane protein, TolC family precursor; Function of strongly homologous gene; transporter.
 
  
 0.410
LHA_3232
Putative HlyD family secretion protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.
 
  
 0.409
Your Current Organism:
Legionella hackeliae
NCBI taxonomy Id: 449
Other names: ATCC 35250, CCUG 31232, CCUG 31232 A, CIP 103844, DSM 19214, JCM 7563, L. hackeliae, NCTC 11979, strain Lansing 2
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