pyrH protein (Legionella hackeliae) - STRING interaction network

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pyrH

Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (247 aa)

Predicted Functional Partners:

frr

0.991

tsf

0.989

rpsB

0.982

ndk

0.959

surE

0.934

LHA_0455

0.929

udk

0.929

pyrF

0.929

LHA_0647

0.900

yjjG

0.900

Your Current Organism:

Legionella hackeliae

NCBI taxonomy Id: 449
Other names: ATCC 35250, CCUG 31232, CCUG 31232 A, CIP 103844, DSM 19214, JCM 7563, L. hackeliae, NCTC 11979, strain Lansing 2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LHA_0455	LHA_0647	LHA_0455	LHA_0647	Putative Uridine-cytidine kinase B; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.	Conserved protein of unknown function; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.	0.900
LHA_0455	pyrF	LHA_0455	LHA_1874	Putative Uridine-cytidine kinase B; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.	Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.	0.904
LHA_0455	pyrH	LHA_0455	LHA_1444	Putative Uridine-cytidine kinase B; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.	Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.	0.929
LHA_0455	surE	LHA_0455	LHA_1938	Putative Uridine-cytidine kinase B; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.	5'-nucleotidase surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.	0.913
LHA_0455	udk	LHA_0455	LHA_0720	Putative Uridine-cytidine kinase B; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.	Uridine kinase.	0.925
LHA_0455	yjjG	LHA_0455	LHA_1014	Putative Uridine-cytidine kinase B; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.	dUMP phosphatase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	0.917
LHA_0647	LHA_0455	LHA_0647	LHA_0455	Conserved protein of unknown function; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.	Putative Uridine-cytidine kinase B; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.	0.900
LHA_0647	ndk	LHA_0647	LHA_1586	Conserved protein of unknown function; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	0.905
LHA_0647	pyrF	LHA_0647	LHA_1874	Conserved protein of unknown function; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.	Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.	0.900
LHA_0647	pyrH	LHA_0647	LHA_1444	Conserved protein of unknown function; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.	Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.	0.900
LHA_0647	surE	LHA_0647	LHA_1938	Conserved protein of unknown function; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.	5'-nucleotidase surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.	0.900
LHA_0647	udk	LHA_0647	LHA_0720	Conserved protein of unknown function; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.	Uridine kinase.	0.900
LHA_0647	yjjG	LHA_0647	LHA_1014	Conserved protein of unknown function; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.	dUMP phosphatase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	0.903
frr	pyrH	LHA_1445	LHA_1444	Ribosome-recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family.	Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.	0.991
frr	rpsB	LHA_1445	LHA_1442	Ribosome-recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family.	30S ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family.	0.997
frr	tsf	LHA_1445	LHA_1443	Ribosome-recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family.	Elongation factor Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family.	0.997
ndk	LHA_0647	LHA_1586	LHA_0647	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	Conserved protein of unknown function; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.	0.905
ndk	pyrH	LHA_1586	LHA_1444	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.	0.959
ndk	rpsB	LHA_1586	LHA_1442	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	30S ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family.	0.965
ndk	tsf	LHA_1586	LHA_1443	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	Elongation factor Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family.	0.479