STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
LHA_1585Homologs of previously reported genes of unknown function. (297 aa)    
Predicted Functional Partners:
LHA_0311
Protein of unknown function; No homology to any previously reported sequences.
    
   0.885
icmJ
IcmJ protein.
    
   0.885
icmO/dotL
Component of Dot/Icm secretion system. ATPase; Function of strongly homologous gene; enzyme.
    
   0.885
icmP/dotM
Component of Dot/Icm secretion system. ATPase component; Homologs of previously reported genes of unknown function; structure.
    
   0.885
miaE
tRNA-(Ms(2)io(6)a)-hydrolase(TRNA hydroxylase).
       0.747
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
       0.722
yfgB
Putative Fe-S containing enzyme; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family.
       0.699
hisS
Histidyl-tRNA synthetase.
       0.640
LHA_1591
Homologs of previously reported genes of unknown function.
       0.635
LHA_1589
Putative DNA-binding protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.
       0.632
Your Current Organism:
Legionella hackeliae
NCBI taxonomy Id: 449
Other names: ATCC 35250, CCUG 31232, CCUG 31232 A, CIP 103844, DSM 19214, JCM 7563, L. hackeliae, NCTC 11979, strain Lansing 2
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.