Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LHA_1871Putative Tfp type 4 fimbrial pilin related signal peptide protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (160 aa)    
Predicted Functional Partners:
LHA_1872
Uracil-DNA glycosylase family 4 protein.
       0.866
ubiA
4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
       0.780
ubiC
4-hydroxybenzoate synthetase; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway; Belongs to the UbiC family.
       0.780
icmE/dotG
Component of the Dot/Icm secretion system. Major component of a channel; Function of strongly homologous gene; structure.
  
     0.720
LHA_3178
Cysteine protease, papain C1 family.
  
     0.715
LHA_0153
Peptidase [Helix-turn-helix type domain]; Function of strongly homologous gene; enzyme.
  
     0.704
LHA_3123
Protein of unknown function; No homology to any previously reported sequences.
  
   
 0.696
LHA_1873
Protein with patatin domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.
       0.681
LHA_1317
Homologs of previously reported genes of unknown function.
 
   
 0.668
LHA_1822
Homologs of previously reported genes of unknown function.
  
     0.629
Your Current Organism:
Legionella hackeliae
NCBI taxonomy Id: 449
Other names: ATCC 35250, CCUG 31232, CCUG 31232 A, CIP 103844, DSM 19214, JCM 7563, L. hackeliae, NCTC 11979, strain Lansing 2
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