| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| LHA_2612 | glyA | LHA_2612 | LHA_2325 | Putative phosphoserine phosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.937 |
| LHA_2612 | pssA | LHA_2612 | LHA_0582 | Putative phosphoserine phosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | CDP-diacylglycerol-serine-O- phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.901 |
| LHA_2612 | trpA | LHA_2612 | LHA_1916 | Putative phosphoserine phosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.900 |
| LHA_2612 | trpB | LHA_2612 | LHA_1917 | Putative phosphoserine phosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.915 |
| glyA | LHA_2612 | LHA_2325 | LHA_2612 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative phosphoserine phosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | 0.937 |
| glyA | pssA | LHA_2325 | LHA_0582 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | CDP-diacylglycerol-serine-O- phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.900 |
| glyA | trpA | LHA_2325 | LHA_1916 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.931 |
| glyA | trpB | LHA_2325 | LHA_1917 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.925 |
| glyA | trpE(G | LHA_2325 | LHA_1421 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Anthranilate synthase [Includes: Glutamine amidotransferase]. | 0.561 |
| pabA | pabB | LHA_2107 | LHA_1578 | Para-aminobenzoate synthase glutamine amidotransferase component II. | Para-aminobenzoate synthase component 1. | 0.999 |
| pabA | trpA | LHA_2107 | LHA_1916 | Para-aminobenzoate synthase glutamine amidotransferase component II. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.976 |
| pabA | trpB | LHA_2107 | LHA_1917 | Para-aminobenzoate synthase glutamine amidotransferase component II. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.966 |
| pabA | trpC | LHA_2107 | LHA_2109 | Para-aminobenzoate synthase glutamine amidotransferase component II. | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.999 |
| pabA | trpD | LHA_2107 | LHA_2108 | Para-aminobenzoate synthase glutamine amidotransferase component II. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.999 |
| pabA | trpE(G | LHA_2107 | LHA_1421 | Para-aminobenzoate synthase glutamine amidotransferase component II. | Anthranilate synthase [Includes: Glutamine amidotransferase]. | 0.992 |
| pabA | trpF | LHA_2107 | LHA_1918 | Para-aminobenzoate synthase glutamine amidotransferase component II. | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. | 0.991 |
| pabB | pabA | LHA_1578 | LHA_2107 | Para-aminobenzoate synthase component 1. | Para-aminobenzoate synthase glutamine amidotransferase component II. | 0.999 |
| pabB | trpA | LHA_1578 | LHA_1916 | Para-aminobenzoate synthase component 1. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.974 |
| pabB | trpB | LHA_1578 | LHA_1917 | Para-aminobenzoate synthase component 1. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.977 |
| pabB | trpC | LHA_1578 | LHA_2109 | Para-aminobenzoate synthase component 1. | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.996 |
