STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
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[Homology]
Score
hmgAHomogentisate 1,2-dioxygenase. (418 aa)    
Predicted Functional Partners:
LHA_0500
Putative 4-hydroxyphenylpyruvate dioxygenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 
 0.995
lly
4-hydroxyphenylpyruvate dioxygenase.
 
 0.995
maiA
Putative maleylacetoacetate isomerase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.
 
 
 0.994
phhA
Phenylalanine-4-hydroxylase.
 
  
 0.944
LHA_1109
Fumarylacetoacetate hydrolase.
 
  
 0.888
ruvA
Holliday junction ATP-dependent DNA helicase ruvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
     
 0.737
ruvC
Crossover junction endodeoxyribonuclease ruvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.
       0.716
LHA_1933
Homologs of previously reported genes of unknown function.
       0.716
LHA_1935
Homologs of previously reported genes of unknown function.
       0.671
LHA_1015
Putative pterin-4-alpha-carbinolamine dehydratase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.
  
  
 0.645
Your Current Organism:
Legionella hackeliae
NCBI taxonomy Id: 449
Other names: ATCC 35250, CCUG 31232, CCUG 31232 A, CIP 103844, DSM 19214, JCM 7563, L. hackeliae, NCTC 11979, strain Lansing 2
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