nlpD protein (Legionella hackeliae) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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[Homology]

Score

nlpD

Novel lipoprotein homolog. (272 aa)

Predicted Functional Partners:

surE

0.866

rpoS

0.864

LHA_1939

0.831

LHA_2120

0.756

malS

0.676

rpoN

0.602

hfq

0.588

tolB

0.577

amiC

0.518

bamD

0.464

Your Current Organism:

Legionella hackeliae

NCBI taxonomy Id: 449
Other names: ATCC 35250, CCUG 31232, CCUG 31232 A, CIP 103844, DSM 19214, JCM 7563, L. hackeliae, NCTC 11979, strain Lansing 2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LHA_1939	malS	LHA_1939	LHA_1940	Homologs of previously reported genes of unknown function.	Putative NAD-dependent malic enzyme 3; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.	0.694
LHA_1939	nlpD	LHA_1939	LHA_1937	Homologs of previously reported genes of unknown function.	Novel lipoprotein homolog.	0.831
LHA_1939	rpoS	LHA_1939	LHA_1936	Homologs of previously reported genes of unknown function.	RNA polymerase sigma factor rpoS; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response.	0.728
LHA_1939	surE	LHA_1939	LHA_1938	Homologs of previously reported genes of unknown function.	5'-nucleotidase surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.	0.866
LHA_2120	amiC	LHA_2120	LHA_2730	Peptidase; Function of strongly homologous gene; enzyme.	N-acetylmuramoyl-L-alanine amidase.	0.528
LHA_2120	nlpD	LHA_2120	LHA_1937	Peptidase; Function of strongly homologous gene; enzyme.	Novel lipoprotein homolog.	0.756
amiC	LHA_2120	LHA_2730	LHA_2120	N-acetylmuramoyl-L-alanine amidase.	Peptidase; Function of strongly homologous gene; enzyme.	0.528
amiC	hfq	LHA_2730	LHA_0008	N-acetylmuramoyl-L-alanine amidase.	Protein hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family.	0.474
amiC	nlpD	LHA_2730	LHA_1937	N-acetylmuramoyl-L-alanine amidase.	Novel lipoprotein homolog.	0.518
bamD	nlpD	LHA_1389	LHA_1937	Conserved protein of unknown function; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.	Novel lipoprotein homolog.	0.464
bamD	rpoN	LHA_1389	LHA_0588	Conserved protein of unknown function; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.	RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	0.474
bamD	tolB	LHA_1389	LHA_1571	Conserved protein of unknown function; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.	Protein tolB; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.	0.603
hfq	amiC	LHA_0008	LHA_2730	Protein hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family.	N-acetylmuramoyl-L-alanine amidase.	0.474
hfq	nlpD	LHA_0008	LHA_1937	Protein hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family.	Novel lipoprotein homolog.	0.588
hfq	rpoN	LHA_0008	LHA_0588	Protein hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family.	RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	0.759
hfq	rpoS	LHA_0008	LHA_1936	Protein hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family.	RNA polymerase sigma factor rpoS; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response.	0.599
malS	LHA_1939	LHA_1940	LHA_1939	Putative NAD-dependent malic enzyme 3; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.	Homologs of previously reported genes of unknown function.	0.694
malS	nlpD	LHA_1940	LHA_1937	Putative NAD-dependent malic enzyme 3; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.	Novel lipoprotein homolog.	0.676
malS	rpoS	LHA_1940	LHA_1936	Putative NAD-dependent malic enzyme 3; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.	RNA polymerase sigma factor rpoS; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response.	0.646
malS	surE	LHA_1940	LHA_1938	Putative NAD-dependent malic enzyme 3; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.	5'-nucleotidase surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.	0.700