STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cspAMajor cold shock protein CspA. (76 aa)    
Predicted Functional Partners:
LHA_1119
Long-chain-fatty-acid--CoA ligase [Beta-ketoacyl synthase active site]; Function of strongly homologous gene; enzyme.
  
 
 0.508
LHA_1995
Beta-ketoacyl synthase (fragment).
  
 
 0.508
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
     
 0.503
rpmE
50S ribosomal protein L31; Binds the 23S rRNA.
   
 
 0.434
LHA_2043
Oxidoreductase dehydrogenase, short chain; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  
   0.430
rpsL
30S ribosomal subunit protein S12; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
   
   0.422
rpmJ
50S ribosomal subunit protein L36; Function of homologous gene experimentally demonstrated in an other organism; structure; Belongs to the bacterial ribosomal protein bL36 family.
   
 
 0.416
rpoZ
DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
   
 
 0.401
rplO
50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.
   
   0.400
Your Current Organism:
Legionella hackeliae
NCBI taxonomy Id: 449
Other names: ATCC 35250, CCUG 31232, CCUG 31232 A, CIP 103844, DSM 19214, JCM 7563, L. hackeliae, NCTC 11979, strain Lansing 2
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.