mutY protein (Legionella hackeliae) - STRING interaction network

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Score

mutY

A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. (363 aa)

Predicted Functional Partners:

dnaN

0.899

LHA_2050

0.870

xhtA

0.688

LHA_2806

0.688

LHA_2049

0.663

LHA_2048

0.659

polA

0.656

LHA_0946

0.643

mutM

0.631

LHA_0743

0.609

Your Current Organism:

Legionella hackeliae

NCBI taxonomy Id: 449
Other names: ATCC 35250, CCUG 31232, CCUG 31232 A, CIP 103844, DSM 19214, JCM 7563, L. hackeliae, NCTC 11979, strain Lansing 2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LHA_0743	mutM	LHA_0743	LHA_2922	Methylated-DNA--protein-cysteine methyltransferase.	Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.	0.564
LHA_0743	mutY	LHA_0743	LHA_2051	Methylated-DNA--protein-cysteine methyltransferase.	A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.	0.609
LHA_0743	polA	LHA_0743	LHA_0215	Methylated-DNA--protein-cysteine methyltransferase.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.	0.807
LHA_0946	dnaN	LHA_0946	LHA_0002	Protein of unknown function; No homology to any previously reported sequences.	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	0.717
LHA_0946	mutY	LHA_0946	LHA_2051	Protein of unknown function; No homology to any previously reported sequences.	A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.	0.643
LHA_0946	polA	LHA_0946	LHA_0215	Protein of unknown function; No homology to any previously reported sequences.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.	0.592
LHA_2048	LHA_2049	LHA_2048	LHA_2049	Homologs of previously reported genes of unknown function.	Homologs of previously reported genes of unknown function.	0.858
LHA_2048	LHA_2050	LHA_2048	LHA_2050	Homologs of previously reported genes of unknown function.	Homologs of previously reported genes of unknown function.	0.659
LHA_2048	mutY	LHA_2048	LHA_2051	Homologs of previously reported genes of unknown function.	A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.	0.659
LHA_2049	LHA_2048	LHA_2049	LHA_2048	Homologs of previously reported genes of unknown function.	Homologs of previously reported genes of unknown function.	0.858
LHA_2049	LHA_2050	LHA_2049	LHA_2050	Homologs of previously reported genes of unknown function.	Homologs of previously reported genes of unknown function.	0.663
LHA_2049	mutY	LHA_2049	LHA_2051	Homologs of previously reported genes of unknown function.	A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.	0.663
LHA_2050	LHA_2048	LHA_2050	LHA_2048	Homologs of previously reported genes of unknown function.	Homologs of previously reported genes of unknown function.	0.659
LHA_2050	LHA_2049	LHA_2050	LHA_2049	Homologs of previously reported genes of unknown function.	Homologs of previously reported genes of unknown function.	0.663
LHA_2050	mutY	LHA_2050	LHA_2051	Homologs of previously reported genes of unknown function.	A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.	0.870
LHA_2806	dnaN	LHA_2806	LHA_0002	Exodeoxyribonuclease III.	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	0.717
LHA_2806	mutY	LHA_2806	LHA_2051	Exodeoxyribonuclease III.	A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.	0.688
LHA_2806	polA	LHA_2806	LHA_0215	Exodeoxyribonuclease III.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.	0.592
LHA_2806	xhtA	LHA_2806	LHA_2805	Exodeoxyribonuclease III.	Endonuclease/exonuclease/phosphatase; Function of strongly homologous gene; enzyme.	0.989
dnaN	LHA_0946	LHA_0002	LHA_0946	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	Protein of unknown function; No homology to any previously reported sequences.	0.717