LHA_2114 protein (Legionella hackeliae) - STRING interaction network

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[Homology]

Score

LHA_2114

DEAD/DEAH box helicase-like protein. (1431 aa)

Predicted Functional Partners:

mutM

0.771

LHA_1064

0.763

radA

0.624

rtcB

0.597

LHA_2112

0.541

LHA_1282

0.522

Your Current Organism:

Legionella hackeliae

NCBI taxonomy Id: 449
Other names: ATCC 35250, CCUG 31232, CCUG 31232 A, CIP 103844, DSM 19214, JCM 7563, L. hackeliae, NCTC 11979, strain Lansing 2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LHA_1064	LHA_2114	LHA_1064	LHA_2114	DNA polymerase III, epsilon subunit; Function of strongly homologous gene; enzyme.	DEAD/DEAH box helicase-like protein.	0.763
LHA_1064	mutM	LHA_1064	LHA_2922	DNA polymerase III, epsilon subunit; Function of strongly homologous gene; enzyme.	Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.	0.843
LHA_1064	radA	LHA_1064	LHA_0638	DNA polymerase III, epsilon subunit; Function of strongly homologous gene; enzyme.	Repair protein radA homolog; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.	0.833
LHA_1282	LHA_2114	LHA_1282	LHA_2114	Homologs of previously reported genes of unknown function.	DEAD/DEAH box helicase-like protein.	0.522
LHA_2112	LHA_2114	LHA_2112	LHA_2114	Homologs of previously reported genes of unknown function.	DEAD/DEAH box helicase-like protein.	0.541
LHA_2112	rtcB	LHA_2112	LHA_2113	Homologs of previously reported genes of unknown function.	Homologs of previously reported genes of unknown function; Belongs to the RtcB family.	0.996
LHA_2114	LHA_1064	LHA_2114	LHA_1064	DEAD/DEAH box helicase-like protein.	DNA polymerase III, epsilon subunit; Function of strongly homologous gene; enzyme.	0.763
LHA_2114	LHA_1282	LHA_2114	LHA_1282	DEAD/DEAH box helicase-like protein.	Homologs of previously reported genes of unknown function.	0.522
LHA_2114	LHA_2112	LHA_2114	LHA_2112	DEAD/DEAH box helicase-like protein.	Homologs of previously reported genes of unknown function.	0.541
LHA_2114	mutM	LHA_2114	LHA_2922	DEAD/DEAH box helicase-like protein.	Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.	0.771
LHA_2114	radA	LHA_2114	LHA_0638	DEAD/DEAH box helicase-like protein.	Repair protein radA homolog; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.	0.624
LHA_2114	rtcB	LHA_2114	LHA_2113	DEAD/DEAH box helicase-like protein.	Homologs of previously reported genes of unknown function; Belongs to the RtcB family.	0.597
mutM	LHA_1064	LHA_2922	LHA_1064	Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.	DNA polymerase III, epsilon subunit; Function of strongly homologous gene; enzyme.	0.843
mutM	LHA_2114	LHA_2922	LHA_2114	Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.	DEAD/DEAH box helicase-like protein.	0.771
mutM	radA	LHA_2922	LHA_0638	Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.	Repair protein radA homolog; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.	0.579
radA	LHA_1064	LHA_0638	LHA_1064	Repair protein radA homolog; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.	DNA polymerase III, epsilon subunit; Function of strongly homologous gene; enzyme.	0.833
radA	LHA_2114	LHA_0638	LHA_2114	Repair protein radA homolog; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.	DEAD/DEAH box helicase-like protein.	0.624
radA	mutM	LHA_0638	LHA_2922	Repair protein radA homolog; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.	Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.	0.579
rtcB	LHA_2112	LHA_2113	LHA_2112	Homologs of previously reported genes of unknown function; Belongs to the RtcB family.	Homologs of previously reported genes of unknown function.	0.996
rtcB	LHA_2114	LHA_2113	LHA_2114	Homologs of previously reported genes of unknown function; Belongs to the RtcB family.	DEAD/DEAH box helicase-like protein.	0.597