Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
LHA_2271Homologs of previously reported genes of unknown function. (305 aa)    
Predicted Functional Partners:
icmE/dotG
Component of the Dot/Icm secretion system. Major component of a channel; Function of strongly homologous gene; structure.
  
     0.558
mscL
Large-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
       0.513
LHA_2270
Protein of unknown function; No homology to any previously reported sequences.
       0.455
enhA
Enhanced entry protein EnhA.
  
     0.450
enhC
Enhanced entry protein EnhC-Beta-lactamase [Sel1-domain][Tetratricopeptide-like helical]; Function of strongly homologous gene; enzyme.
  
     0.446
LHA_0943
Protein of unknown function; No homology to any previously reported sequences.
  
   
 0.445
LHA_2930
Homologs of previously reported genes of unknown function.
  
     0.443
dotA
Component of the Dot/Icm secretion system; Function of strongly homologous gene; membrane component.
  
     0.435
IcmF
IcmF protein; Function of strongly homologous gene; factor.
  
     0.430
LHA_1417
Putative Enhanced entry protein EnhA; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; cell process.
  
     0.428
Your Current Organism:
Legionella hackeliae
NCBI taxonomy Id: 449
Other names: ATCC 35250, CCUG 31232, CCUG 31232 A, CIP 103844, DSM 19214, JCM 7563, L. hackeliae, NCTC 11979, strain Lansing 2
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