STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
glnBNitrogen regulatory protein P-II; Belongs to the P(II) protein family. (112 aa)    
Predicted Functional Partners:
glnD
[Protein-PII] uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.
 
 
 
 0.847
LHA_0495
Methyltransferase [TPR domain][Sel1-like domain]; Function of strongly homologous gene; enzyme.
    
 
 0.734
LHA_3254
Protein of unknown function; No homology to any previously reported sequences.
   
 
 0.720
LHA_0129
Protein of unknown function; No homology to any previously reported sequences.
    
 
 0.714
LHA_2336
Protein of unknown function [Tetratricopeptide region]; No homology to any previously reported sequences.
    
 
 0.714
LHA_2521
Conserved protein of unknown function [TPR Domain]; Homologs of previously reported genes of unknown function.
    
 
 0.714
LHA_3106
TPR repeat containing protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.
    
 
 0.714
LHA_3107
Homologs of previously reported genes of unknown function.
    
 
 0.714
LHA_2408
Homologs of previously reported genes of unknown function.
     
 0.619
nadE
Putative glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
  
  
 0.584
Your Current Organism:
Legionella hackeliae
NCBI taxonomy Id: 449
Other names: ATCC 35250, CCUG 31232, CCUG 31232 A, CIP 103844, DSM 19214, JCM 7563, L. hackeliae, NCTC 11979, strain Lansing 2
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.