LHA_2774 protein (Legionella hackeliae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

LHA_2774

Homologs of previously reported genes of unknown function; Belongs to the pirin family. (237 aa)

Predicted Functional Partners:

LHA_2775

0.664

hemC

0.517

hemD

0.517

LHA_2772

0.517

hemY

0.517

azoR

0.459

Your Current Organism:

Legionella hackeliae

NCBI taxonomy Id: 449
Other names: ATCC 35250, CCUG 31232, CCUG 31232 A, CIP 103844, DSM 19214, JCM 7563, L. hackeliae, NCTC 11979, strain Lansing 2

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LHA_2772	LHA_2774	LHA_2772	LHA_2774	Homologs of previously reported genes of unknown function.	Homologs of previously reported genes of unknown function; Belongs to the pirin family.	0.517
LHA_2772	LHA_2775	LHA_2772	LHA_2775	Homologs of previously reported genes of unknown function.	Protein of unknown function; No homology to any previously reported sequences.	0.452
LHA_2772	hemC	LHA_2772	LHA_2770	Homologs of previously reported genes of unknown function.	Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.	0.918
LHA_2772	hemD	LHA_2772	LHA_2771	Homologs of previously reported genes of unknown function.	Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.	0.992
LHA_2772	hemY	LHA_2772	LHA_2773	Homologs of previously reported genes of unknown function.	Protoporphyrinogen IX and coproporphyrinogen III oxidase HemY.	0.990
LHA_2774	LHA_2772	LHA_2774	LHA_2772	Homologs of previously reported genes of unknown function; Belongs to the pirin family.	Homologs of previously reported genes of unknown function.	0.517
LHA_2774	LHA_2775	LHA_2774	LHA_2775	Homologs of previously reported genes of unknown function; Belongs to the pirin family.	Protein of unknown function; No homology to any previously reported sequences.	0.664
LHA_2774	azoR	LHA_2774	LHA_0197	Homologs of previously reported genes of unknown function; Belongs to the pirin family.	FMN-dependent NADH-azoreductase; Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity; Belongs to the azoreductase type 1 family.	0.459
LHA_2774	hemC	LHA_2774	LHA_2770	Homologs of previously reported genes of unknown function; Belongs to the pirin family.	Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.	0.517
LHA_2774	hemD	LHA_2774	LHA_2771	Homologs of previously reported genes of unknown function; Belongs to the pirin family.	Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.	0.517
LHA_2774	hemY	LHA_2774	LHA_2773	Homologs of previously reported genes of unknown function; Belongs to the pirin family.	Protoporphyrinogen IX and coproporphyrinogen III oxidase HemY.	0.517
LHA_2775	LHA_2772	LHA_2775	LHA_2772	Protein of unknown function; No homology to any previously reported sequences.	Homologs of previously reported genes of unknown function.	0.452
LHA_2775	LHA_2774	LHA_2775	LHA_2774	Protein of unknown function; No homology to any previously reported sequences.	Homologs of previously reported genes of unknown function; Belongs to the pirin family.	0.664
LHA_2775	hemC	LHA_2775	LHA_2770	Protein of unknown function; No homology to any previously reported sequences.	Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.	0.452
LHA_2775	hemD	LHA_2775	LHA_2771	Protein of unknown function; No homology to any previously reported sequences.	Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.	0.452
LHA_2775	hemY	LHA_2775	LHA_2773	Protein of unknown function; No homology to any previously reported sequences.	Protoporphyrinogen IX and coproporphyrinogen III oxidase HemY.	0.452
azoR	LHA_2774	LHA_0197	LHA_2774	FMN-dependent NADH-azoreductase; Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity; Belongs to the azoreductase type 1 family.	Homologs of previously reported genes of unknown function; Belongs to the pirin family.	0.459
hemC	LHA_2772	LHA_2770	LHA_2772	Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.	Homologs of previously reported genes of unknown function.	0.918
hemC	LHA_2774	LHA_2770	LHA_2774	Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.	Homologs of previously reported genes of unknown function; Belongs to the pirin family.	0.517
hemC	LHA_2775	LHA_2770	LHA_2775	Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.	Protein of unknown function; No homology to any previously reported sequences.	0.452