LHA_2817 protein (Legionella hackeliae) - STRING interaction network

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Score

LHA_2817

Heat shock Hsp20 domain protein. (191 aa)

Predicted Functional Partners:

clpA

0.673

clpB

0.673

LHA_2816

0.562

htpG

0.520

dnaK

0.489

grpE

0.400

Your Current Organism:

Legionella hackeliae

NCBI taxonomy Id: 449
Other names: ATCC 35250, CCUG 31232, CCUG 31232 A, CIP 103844, DSM 19214, JCM 7563, L. hackeliae, NCTC 11979, strain Lansing 2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LHA_2816	LHA_2817	LHA_2816	LHA_2817	Protein of unknown function; No homology to any previously reported sequences.	Heat shock Hsp20 domain protein.	0.562
LHA_2817	LHA_2816	LHA_2817	LHA_2816	Heat shock Hsp20 domain protein.	Protein of unknown function; No homology to any previously reported sequences.	0.562
LHA_2817	clpA	LHA_2817	LHA_1243	Heat shock Hsp20 domain protein.	ATP-dependent Clp protease ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family.	0.673
LHA_2817	clpB	LHA_2817	LHA_2207	Heat shock Hsp20 domain protein.	Chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.	0.673
LHA_2817	dnaK	LHA_2817	LHA_0671	Heat shock Hsp20 domain protein.	Chaperone protein dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.489
LHA_2817	grpE	LHA_2817	LHA_0670	Heat shock Hsp20 domain protein.	Protein grpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]	0.400
LHA_2817	htpG	LHA_2817	LHA_1814	Heat shock Hsp20 domain protein.	Chaperone protein htpG; Molecular chaperone. Has ATPase activity.	0.520
clpA	LHA_2817	LHA_1243	LHA_2817	ATP-dependent Clp protease ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family.	Heat shock Hsp20 domain protein.	0.673
clpA	dnaK	LHA_1243	LHA_0671	ATP-dependent Clp protease ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family.	Chaperone protein dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.973
clpA	grpE	LHA_1243	LHA_0670	ATP-dependent Clp protease ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family.	Protein grpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]	0.887
clpA	htpG	LHA_1243	LHA_1814	ATP-dependent Clp protease ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family.	Chaperone protein htpG; Molecular chaperone. Has ATPase activity.	0.781
clpB	LHA_2817	LHA_2207	LHA_2817	Chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.	Heat shock Hsp20 domain protein.	0.673
clpB	dnaK	LHA_2207	LHA_0671	Chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.	Chaperone protein dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.973
clpB	grpE	LHA_2207	LHA_0670	Chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.	Protein grpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]	0.872
clpB	htpG	LHA_2207	LHA_1814	Chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.	Chaperone protein htpG; Molecular chaperone. Has ATPase activity.	0.781
dnaK	LHA_2817	LHA_0671	LHA_2817	Chaperone protein dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Heat shock Hsp20 domain protein.	0.489
dnaK	clpA	LHA_0671	LHA_1243	Chaperone protein dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	ATP-dependent Clp protease ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family.	0.973
dnaK	clpB	LHA_0671	LHA_2207	Chaperone protein dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.	0.973
dnaK	grpE	LHA_0671	LHA_0670	Chaperone protein dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Protein grpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]	0.999
dnaK	htpG	LHA_0671	LHA_1814	Chaperone protein dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Chaperone protein htpG; Molecular chaperone. Has ATPase activity.	0.998